https://scholars.lib.ntu.edu.tw/handle/123456789/626918
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu, Hao-Yu | en_US |
dc.contributor.author | CHIEN-TING PAN | en_US |
dc.contributor.author | CHIAO-FENG CHENG | en_US |
dc.contributor.author | Lin, Chi-Ying | en_US |
dc.contributor.author | SHENG-NAN CHANG | en_US |
dc.contributor.author | Chen, Yi-Chung | en_US |
dc.contributor.author | CHIH-YUAN WANG | en_US |
dc.contributor.author | YEN-FU CHEN | en_US |
dc.contributor.author | CHUNG-YU CHEN | en_US |
dc.contributor.author | MATTHEW HUEI-MING MA | en_US |
dc.contributor.author | JUEY-JEN HWANG | en_US |
dc.date.accessioned | 2023-01-04T08:24:51Z | - |
dc.date.available | 2023-01-04T08:24:51Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 0929-6646 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/626918 | - |
dc.description.abstract | Since December 2019, the outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly around the world. The severity of COVID-19 ranges from asymptomatic carriers to severe acute respiratory distress syndrome (ARDS). Accumulating evidence has shown that COVID-19 may be associated with multiple organ complications including cardiac injury, viral myositis and neurological deficits. Numerous laboratory biomarkers including lymphocytes, platelets, lactate dehydrogenase and creatine kinase (CK) have been associated with the prognostic outcomes of patients with COVID-19. However, dynamic correlations between levels of biomarkers and clinical course have not been studied. Herein, we report a 74-year-old female patient with severe COVID-19 which progressed to ARDS requiring intubation and mechanical ventilation. The laboratory findings showed lymphopenia, hypogammaglobulinemia, and elevated inflammatory biomarkers and CK. She received intensive therapy with hydroxychloroquine, lopinavir/ritonavir, and azithromycin with limited effects. Immunomodulatory treatments with high dose intravenous immunoglobulin and baricitinib were prescribed with satisfactory biochemical, radiographic and clinical recovery. We found an interesting correlation between serum CK elevation and inflammatory biomarkers, which reflected clinical improvement. This case demonstrates that inflammatory biomarkers, cytokines, and CK level correlated with disease severity and treatment response, and combined use of intravenous immunoglobulin and baricitinib is a potential treatment in patients with severe COVID-19. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER TAIWAN | en_US |
dc.relation.ispartof | Journal of the Formosan Medical Association = Taiwan yi zhi | en_US |
dc.subject | ARDS; Baricitinib; COVID-19; Creatine kinase; IVIg | en_US |
dc.title | Combined intravenous immunoglobulin and baricitinib treatment for severe COVID-19 with rhabdomyolysis: A case report | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jfma.2021.03.014 | - |
dc.identifier.pmid | 33838985 | - |
dc.identifier.scopus | 2-s2.0-85103936468 | - |
dc.identifier.isi | WOS:000687322100013 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85103936468 | - |
dc.relation.pages | 1777 | en_US |
dc.relation.journalvolume | 120 | en_US |
dc.relation.journalissue | 9 | en_US |
dc.relation.pageend | 1781 | en_US |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUHYL | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUHYL | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Emergency Medicine | - |
crisitem.author.dept | Emergency Medicine-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.orcid | 0000-0002-8618-9945 | - |
crisitem.author.orcid | 0000-0002-2663-5042 | - |
crisitem.author.orcid | 0000-0002-6742-3935 | - |
crisitem.author.orcid | 0000-0001-9002-7255 | - |
crisitem.author.orcid | 0000-0002-4388-9984 | - |
crisitem.author.orcid | 0000-0001-6437-0455 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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