https://scholars.lib.ntu.edu.tw/handle/123456789/627168
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yu, Chih-Hsiang | en_US |
dc.contributor.author | Wu, Gang | en_US |
dc.contributor.author | Chang, Chia-Ching | en_US |
dc.contributor.author | SHIANN-TANG JOU | en_US |
dc.contributor.author | MENG-YAO LU | en_US |
dc.contributor.author | Lin, Kai-Hsin | en_US |
dc.contributor.author | Chen, Shu-Huey | en_US |
dc.contributor.author | Wu, Kang-Hsi | en_US |
dc.contributor.author | Huang, Fang-Liang | en_US |
dc.contributor.author | Cheng, Chao-Neng | en_US |
dc.contributor.author | HSIU-HAO CHANG | en_US |
dc.contributor.author | Hedges, Dale | en_US |
dc.contributor.author | Wang, Jinn-Li | en_US |
dc.contributor.author | Yen, Hsiu-Ju | en_US |
dc.contributor.author | MENG-JU LI | en_US |
dc.contributor.author | SHU-WEI CHOU | en_US |
dc.contributor.author | Hung, Chen-Ting | en_US |
dc.contributor.author | Lin, Ze-Shiang | en_US |
dc.contributor.author | Lin, Chien-Yu | en_US |
dc.contributor.author | Chen, Hsuan-Yu | en_US |
dc.contributor.author | Ni, Yu-Ling | en_US |
dc.contributor.author | Hsu, Yin-Chen | en_US |
dc.contributor.author | Lin, Dong-Tsamn | en_US |
dc.contributor.author | SHU-WHA LIN | en_US |
dc.contributor.author | Yang, Jun J | en_US |
dc.contributor.author | Pui, Ching-Hon | en_US |
dc.contributor.author | SUNG-LIANG YU | en_US |
dc.contributor.author | YUNG-LI YANG | en_US |
dc.date.accessioned | 2023-01-11T07:29:51Z | - |
dc.date.available | 2023-01-11T07:29:51Z | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 15251578 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/627168 | - |
dc.description.abstract | Identification of specific leukemia subtypes is a key to successful risk-directed therapy in childhood acute lymphoblastic leukemia (ALL). Although RNA sequencing (RNA-seq) is the best approach to identify virtually all specific leukemia subtypes, the routine use of this method is too costly for patients in resource-limited countries. This study enrolled 295 patients with pediatric ALL from 2010 to 2020. Routine screening could identify major cytogenetic alterations in approximately 69% of B-cell ALL (B-ALL) cases by RT-PCR, DNA index, and multiplex ligation-dependent probe amplification. STIL-TAL1 was present in 33% of T-cell ALL (T-ALL) cases. The remaining samples were submitted for RNA-seq. More than 96% of B-ALL cases and 74% of T-ALL cases could be identified based on the current molecular classification using this sequential approach. Patients with Philadelphia chromosome-like ALL constituted only 2.4% of the entire cohort, a rate even lower than those with ZNF384-rearranged (4.8%), DUX4-rearranged (6%), and Philadelphia chromosome-positive (4.4%) ALL. Patients with ETV6-RUNX1, high hyperdiploidy, PAX5 alteration, and DUX4 rearrangement had favorable prognosis, whereas those with hypodiploid and KMT2A and MEF2D rearrangement ALL had unfavorable outcomes. With the use of multiplex ligation-dependent probe amplification, DNA index, and RT-PCR in B-ALL and RT-PCR in T-ALL followed by RNA-seq, childhood ALL can be better classified to improve clinical assessments. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | The Journal of molecular diagnostics : JMD | en_US |
dc.title | Sequential Approach to Improve the Molecular Classification of Childhood Acute Lymphoblastic Leukemia | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jmoldx.2022.08.001 | - |
dc.identifier.pmid | 35963521 | - |
dc.identifier.scopus | 2-s2.0-85140963467 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85140963467 | - |
dc.relation.journalvolume | 24 | en_US |
dc.relation.journalissue | 11 | en_US |
dc.relation.pageend | 1206 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUHHC | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Medical Device and Imaging | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-1483-0403 | - |
crisitem.author.orcid | 0000-0003-4461-9967 | - |
crisitem.author.orcid | 0000-0003-1832-8509 | - |
crisitem.author.orcid | 0000-0002-1838-6576 | - |
crisitem.author.orcid | 0000-0001-6748-5581 | - |
crisitem.author.orcid | 0000-0003-4535-9036 | - |
crisitem.author.orcid | 0000-0002-3598-7218 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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