|Title:||Do all the patients with gastric parietal cell antibodies have pernicious anemia?||Authors:||Sun, A.
Wang, Y. P.
Lin, H. P.
Chiang, C. P.
|Keywords:||Gastric parietal cell antibody | Hemoglobin | Iron | Mean corpuscular volume | Pernicious anemia | Vitamin B12||Issue Date:||1-May-2013||Publisher:||WILEY||Journal Volume:||19||Journal Issue:||4||Start page/Pages:||381||Source:||Oral Diseases||Abstract:||
Objective: This study evaluated whether all the patients with serum gastric parietal cell antibody (GPCA) positivity had pernicious anemia (PA). Materials and Methods: The blood hemoglobin (Hb), iron, and vitamin B12 concentrations, and mean corpuscular volume (MCV) in 124 GPCA-positive patients were measured and compared with the corresponding data in 124 age- and sex-matched healthy controls. PA was defined by World Health Organization (WHO) as having an Hb concentration < 13 g dl-1 for men and < 12 g dl-1 for women, an MCV ≥ 100 fl, and a serum vitamin B12 level < 200 pg ml-1. Results: We found that 20, 25, and 20 GPCA-positive patients had deficiencies of Hb (men < 13 g dl-1, women < 12 g dl-1), iron (<60 μg dl-1), and vitamin B12 (<200 pg ml-1), respectively. Moreover, 16 GPCA-positive patients had abnormally high MCV (≥100 fl). GPCA-positive patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency and of abnormally high MCV (all P-values < 0.001) than healthy controls. However, only 12.9% of 124 GPCA-positive patients were diagnosed as having PA by the WHO definition. Conclusion: Only 12.9% of GPCA-positive patients are discovered to have PA by the WHO definition. © 2012 John Wiley & Sons A/S.
|Appears in Collections:||臨床牙醫學研究所|
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