https://scholars.lib.ntu.edu.tw/handle/123456789/629772
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chang, Jung-Wei | en_US |
dc.contributor.author | HSIN-CHANG CHEN | en_US |
dc.contributor.author | Hu, Heng-Zhao | en_US |
dc.contributor.author | Chang, Wan-Ting | en_US |
dc.contributor.author | Huang, Po-Chin | en_US |
dc.contributor.author | Wang, I-Jen | en_US |
dc.date.accessioned | 2023-03-27T06:46:53Z | - |
dc.date.available | 2023-03-27T06:46:53Z | - |
dc.date.issued | 2022-06-17 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/629772 | - |
dc.description.abstract | Whether low-dose phthalate exposure triggers asthma among children, and its underlying mechanisms, remain debatable. Here, we evaluated the individual and mixed effects of low-dose phthalate exposure on children with asthma and five (oxidative/nitrosative stress/lipid peroxidation) mechanistic biomarkers-8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-nitroguanine (8-NO2Gua), 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA), 8-isoprostaglandin F2α (8-isoPF2α), and malondialdehyde (MDA)-using a propensity score-matched case-control study (case vs. control = 41 vs. 111). The median monobenzyl phthalate (MBzP) concentrations in the case group were significantly higher than those in the control group (3.94 vs. 2.52 ng/mL, p = 0.02), indicating that dust could be an important source. After adjustment for confounders, the associations of high monomethyl phthalate (MMP) (75th percentile) with 8-NO2Gua (adjusted odds ratio (aOR): 2.66, 95% confidence interval (CI): 1.03-6.92) and 8-isoPF2α (aOR: 4.04, 95% CI: 1.51-10.8) and the associations of mono-iso-butyl phthalate (MiBP) with 8-isoPF2α (aOR: 2.96, 95% CI: 1.13-7.79) were observed. Weighted quantile sum regression revealed that MBzP contributed more than half of the association (56.8%), followed by MiBP (26.6%) and mono-iso-nonyl phthalate (MiNP) (8.77%). Our findings supported the adjuvant effect of phthalates in enhancing the immune system response. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | Biomedicines | en_US |
dc.subject | asthma; oxidative stress; phthalates; propensity score matching | en_US |
dc.title | Phthalate Exposure and Oxidative/Nitrosative Stress in Childhood Asthma: A Nested Case-Control Study with Propensity Score Matching | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/biomedicines10061438 | - |
dc.identifier.pmid | 35740459 | - |
dc.identifier.scopus | 2-s2.0-85132713177 | - |
dc.identifier.isi | WOS:000817409700001 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85132713177 | - |
dc.relation.journalvolume | 10 | en_US |
dc.relation.journalissue | 6 | en_US |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.orcid | 0000-0003-4879-3639 | - |
顯示於: | 食品安全與健康研究所 |
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