S-Allylcysteine Potently Protects against PhIP-Induced DNA Damage via Nrf2/AhR Signaling Pathway Modulation in Normal Human Colonic Mucosal Epithelial Cells
Journal
Molecular nutrition & food research
Journal Volume
66
Journal Issue
16
Date Issued
2022-08
Author(s)
Lin, Wei-Sheng
Lai, Ying-Jang
Nagabhushanam, Kalyanam
Ho, Chi-Tang
MIN-HSIUNG PAN
Abstract
This study aims to investigate whether S-allylcysteine (SAC) exerts chemoprophylactic effects on foodborne carcinogenicity caused by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in normal human colonic mucosal epithelial cells.
Subjects
Nrf2/AhR; PhIP; S-allylcysteine; chemoprevention; normal colonic epithelia cells
Publisher
WILEY
Type
journal article