https://scholars.lib.ntu.edu.tw/handle/123456789/630164
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHIEN-AN YAO | en_US |
dc.contributor.author | Yen, Tsung-Yi | en_US |
dc.contributor.author | SANDY HUEY-JEN HSU | en_US |
dc.contributor.author | TA-CHEN SU | en_US |
dc.date.accessioned | 2023-04-12T08:24:55Z | - |
dc.date.available | 2023-04-12T08:24:55Z | - |
dc.date.issued | 2023-02-16 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/630164 | - |
dc.description.abstract | (1) Background: Diabetes mellitus (DM) is a significant health problem and is associated with dyslipidemia; however, the association between glycative stress, in terms of glycated hemoglobin (HbA1c), and atherogenic dyslipidemia in hyperlipidemic patients with and without DM has rarely been reported. (2) Methods: We prospectively recruited 949 hyperlipidemic patients from the Lipid Clinic of the National Taiwan University Hospital. HbA1c and fasting serum lipids, including total cholesterol (TC), high- and low-density lipoprotein cholesterol (HDL-C and LDL-C), small dense LDL-C (sdLDL-C), very low-density lipoprotein cholesterol (VLDL-C), triglycerides, and advanced glycation end-products (AGEs), were measured. After fasting for 10-14 h, all subjects except those with DM underwent a standard oral glucose tolerance test (OGTT) with 75 g of glucose loading. All subjects were asked to discontinue the use of lipid-lowering agents for 8 weeks before recruitment. (3) Results: Patients with DM had a higher prevalence of hypertension and higher levels of triglyceride, TC/HDL-C ratio, AGEs, VLDL-C, and sdLDL-C. Among patients with higher HbA1c, the serum VLDL-C, AGEs, and TC/HDL-C ratio were significantly higher than those with lower HbA1c. After adjustment for covariates, multiple logistic regression analyses revealed different groups of dysglycemia with higher HbA1c had a higher odds ratio for TC/HDL-C ≥ 5, sdLDL-C ≥ 75th percentile, VLDL-C ≥ 75th percentile and AGEs ≥ 75th percentile. (4) Conclusions: A higher HbA1c was associated with a significant increase in the risk of atherogenic dyslipidemia and AGEs levels in patients with hyperlipidemia. The findings can be very promising in clinical application. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | Cells | en_US |
dc.subject | HbA1c; advanced glycation end-products; atherogenic dyslipidemia; glycative stress | en_US |
dc.title | Glycative Stress, Glycated Hemoglobin, and Atherogenic Dyslipidemia in Patients with Hyperlipidemia | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/cells12040640 | - |
dc.identifier.pmid | 36831307 | - |
dc.identifier.scopus | 2-s2.0-85148853217 | - |
dc.identifier.isi | WOS:000944966700001 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85148853217 | - |
dc.relation.journalvolume | 12 | en_US |
dc.relation.journalissue | 4 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Environmental and Occupational Medicine | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-8074-6379 | - |
crisitem.author.orcid | 0000-0002-5539-4858 | - |
crisitem.author.orcid | 0000-0001-7523-7166 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 環境與職業健康科學研究所 |
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