https://scholars.lib.ntu.edu.tw/handle/123456789/630724
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu, Yu Hsueh | en_US |
dc.contributor.author | Lee, Yi Pang | en_US |
dc.contributor.author | JULIA YU-FONG CHANG | en_US |
dc.contributor.author | YI-PING WANG | en_US |
dc.contributor.author | CHUN-PIN CHIANG | en_US |
dc.contributor.author | ANDY SUN | en_US |
dc.date.accessioned | 2023-05-03T14:50:13Z | - |
dc.date.available | 2023-05-03T14:50:13Z | - |
dc.date.issued | 2023-04-01 | - |
dc.identifier.issn | 19917902 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/630724 | - |
dc.description.abstract | Background/purpose: Oral submucous fibrosis (OSF) is a progressive fibrotic oral mucosal disease associated with betel quid chewing. This study evaluated whether Taiwanese male OSF patients with folic acid (FA) deficiency (the serum FA level ≤6 ng/mL, so-called FA-deficient OSF patients) had high frequencies of blood hemoglobin (Hb) and serum iron and vitamin B12 deficiencies, and serum gastric parietal cell antibody (GPCA) positivity. Materials and methods: The blood Hb and serum iron, vitamin B12, FA, and GPCA concentrations in 59 Taiwanese male FA-deficient OSF patients were measured and compared with the corresponding data in 118 age-matched healthy male control subjects. Results: We found that 3 (5.1%), 35 (59.3%), and 7 (11.9%) of the 59 FA-deficient OSF patients had blood Hb (<13 g/dL) and serum vitamin B12 (≤450 pg/mL) deficiencies, and serum GPCA positivity, respectively. Furthermore, 59 FA-deficient OSF patients had significantly higher frequencies of serum vitamin B12 deficiency and serum GPCA positivity than 118 healthy control subjects (all P-values <0.05). Of the 3 anemic FA-deficient OSF patients, one had macrocytic anemia and the other two had thalassemia trait-induced anemia. Conclusion: We conclude that Taiwanese male FA-deficient OSF patients have high frequencies of serum vitamin B12 deficiency and GPCA positivity than healthy control subjects. The vitamin B12 and FA deficiencies in FA-deficient OSF patients are more likely due to OSF symptoms and signs-caused insufficient intake, difficulty in chewing and swallowing, and malabsorption of food fragment-bound vitamin B12 and FA rather than the GPCA positivity in these OSF patients. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER TAIWAN | en_US |
dc.relation.ispartof | Journal of Dental Sciences | en_US |
dc.subject | Anemia | Folic acid deficiency | Gastric parietal cell antibody | Oral submucous fibrosis | Vitamin B12 deficiency | en_US |
dc.title | Higher frequencies of anemia, vitamin B12 deficiency, and gastric parietal cell antibody positivity in folic acid-deficient Taiwanese male oral submucous fibrosis patients | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jds.2023.01.014 | - |
dc.identifier.pmid | 37021251 | - |
dc.identifier.scopus | 2-s2.0-85148713842 | - |
dc.identifier.isi | WOS:000956441300001 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85148713842 | - |
dc.relation.pages | 801 | en_US |
dc.relation.journalvolume | 18 | en_US |
dc.relation.journalissue | 2 | en_US |
dc.relation.pageend | 807 | en_US |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.orcid | 0000-0002-3880-3787 | - |
crisitem.author.orcid | 0000-0001-9574-2194 | - |
crisitem.author.orcid | 0000-0002-6190-7162 | - |
crisitem.author.orcid | 0000-0002-4912-5424 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 牙醫學系 |
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