Hydrops fetalis caused by severe α-thalassemia
Journal
Early Human Development
Journal Volume
29
Journal Issue
1-3
Date Issued
1992-01-01
Author(s)
Abstract
Alpha-thalassemia is a prevalent condition in South East Asia and spreading because of increasing immigration. Hemodynamic study of Hb Bart's hydrops fetalis, the most severe form of a-thalassemia, showed the fetuses were in a hyperdynamic circulatory state and were also more acidotic, hypoxic, and hypercarvic than normal fetuses. The most common molecular defects of Hb Bart's hydrops fetalis was the Southeast Asia type deletion. Prenatal diagnosis of Hb Bart's hydrops fetalis and HbH diseases has been achieved using chorionic villi sampling or fetal blood sampling. © 1992.
Subjects
hydrops fetalis | prenatal diagnosis | α-thalassemia
Type
journal article