https://scholars.lib.ntu.edu.tw/handle/123456789/631557
標題: | Association of a simple SACAF score with bystander witnessed sudden death due to ventricular tachyarrhythmias in a multicenter cohort | 作者: | Wu, Mei-Yao Wen, Ming-Shien Chen, Mien-Cheng CHIA-TI TSAI Wu, Tsu-Juey Lee, Wei-Chieh Lin, Yen-Nien Chang, Shih-Sheng Chang, Kuan-Cheng |
關鍵字: | HOSPITAL CARDIAC-ARREST; INTERNATIONAL LIAISON COMMITTEE; EUROPEAN-RESUSCITATION-COUNCIL; AMERICAN-HEART-ASSOCIATION; INDEPENDENT RISK-FACTOR; ATRIAL-FIBRILLATION; ATHEROSCLEROSIS-RISK; STROKE-FOUNDATION; UNEXPECTED DEATH; TASK-FORCE | 公開日期: | 4-十一月-2021 | 出版社: | NATURE PORTFOLIO | 卷: | 11 | 期: | 1 | 起(迄)頁: | 21665 | 來源出版物: | Scientific reports | 摘要: | Out-of-hospital cardiac arrest (OHCA) remains a major threat to public health worldwide. OHCA patients presenting initial shockable ventricular tachycardia/ventricular fibrillation (VT/VF) rhythm have a better survival rate. We sought to develop a simple SACAF score to discriminate VT/VF from non-VT/VF OHCAs based on the Taiwan multicenter hospital-based registry database. We analyzed the in- and pre-hospital data, including demographics, baseline comorbidities, response times, automated external defibrillator information, and the 12-lead ECG recording closest to the OHCA event in bystander-witnessed OHCA patients. Among the 461 study patients, male sex (OR 2.54, 95% CI = 1.32-4.88, P = 0.005), age ≤ 65 years (OR 2.78, 95% CI = 1.64-4.70, P < 0.001), cardiovascular diseases (OR 2.97, 95% CI = 1.73-5.11, P < 0.001), and atrial fibrillation (AF) (OR 2.36, 95% CI = 1.17-4.76, P = 0.017) were independent risk factors for VT/VF OHCA (n = 81) compared with non-VT/VF OHCA (n = 380). A composite SACAF score was developed (male Sex, Age ≤ 65 years, Cardiovascular diseases, and AF) and compared with the performance of a modified CHA2DS2-VASc score (Cardiovascular diseases, Hypertension, Age ≥ 75 years, Diabetes, previous Stroke, Vascular disease, Age 65-74 years, female Sex category). The area under the receiver operating characteristic curve (AUC) of the SACAF was 0.739 (95% CI = 0.681-0.797, P < 0.001), whereas the AUC of the modified CHA2DS2-VASc was 0.474 (95% CI = 0.408-0.541, P = 0.464). A SACAF score of ≥ 2 was useful in discriminating VT/VF from non-VT/VF OHCAs with a sensitivity of 0.75 and a specificity of 0.60. In conclusion, the simple SACAF score appears to be useful in discriminating VT/VF from non-VT/VF bystander-witnessed OHCAs and the findings may also shed light on future mechanistic evaluation. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/631557 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-00940-0 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。