https://scholars.lib.ntu.edu.tw/handle/123456789/632651
Title: | Zinc supplementation augments the suppressive effects of repurposed NF-κB inhibitors on ACE2 expression in human lung cell lines | Authors: | Lee, Ming-Cheng YIN-KAI CHEN Tsai-Wu, Jyy-Jih Hsu, Yih-Jen BOR-RU LIN |
Keywords: | ACE2; Emetine; NF-kappa B; ROS; Triclabendazole; Zinc | Issue Date: | 1-Sep-2021 | Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | Journal Volume: | 280 | Start page/Pages: | 119752 | Source: | Life sciences | Abstract: | Angiotensin-converting enzyme 2 (ACE2) is a key negative regulator of the renin-angiotensin system and also a major receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we reveal a role for NF-κB in human lung cell expression of ACE2, and we further explore the potential utility of repurposing NF-κB inhibitors to downregulate ACE2. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/632651 | ISSN: | 0024-3205 | DOI: | 10.1016/j.lfs.2021.119752 |
Appears in Collections: | 醫學系 |
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