https://scholars.lib.ntu.edu.tw/handle/123456789/633229
標題: | Dengue Virus Ribonucleic Acid Detection Rates in Blood Donors Correlate With Local Infection Incidences During a Dengue Outbreak in Taiwan | 作者: | Chen, Yun Yuan Lu, Chi Te Tsai, Mei Hua Yang, Cheng Fen Shu, Pei Yun KEVIN CHIA-WEN WU Chen, Jen Wei Hung, Chi Ming Wei, Sheng Tang Hou, Sheng Mou PEI-JER CHEN |
關鍵字: | blood safety | dengue | transfusion-transmitted infection | 公開日期: | 1-五月-2022 | 卷: | 225 | 期: | 9 | 來源出版物: | Journal of Infectious Diseases | 摘要: | Background: Evidence for mitigation of transfusion-transmitted dengue informed by surveillance data is lacking. In this study, we evaluated the risk of positive dengue viral (DENV) ribonucleic acid (RNA) from blood transfusions during a large outbreak in Taiwan. Methods: Serum collected from blood donors living in districts experiencing the dengue epidemic were tested for DENV RNA using a qualitative transcription-mediated nucleic acid amplification assay (TMA). The TMA-reactive specimens were further tested for immunoglobulin (Ig)M and IgG antibodies, nonstructural protein 1 (NS1) antigen, and viral RNA by reverse-transcription polymerase chain reaction. We estimated DENV RNA prevalence and the number of DENV infections among blood donors. Results: A total of 4976 specimens were tested for DENV RNA, and 21 were TMA-reactive. The detection rate was 0.84 (95% confidence interval [CI], 0.15-4.73), 3.36 (95% CI, 1.31-8.60), and 6.19 (95% CI, 3.14-12.17) per 1000 donors in districts where the weekly dengue incidence was 5-50, 50-200, and 200 or more per 100 000 residents, respectively. Alanine aminotransferase screening only detected 4.4% of TMA-reactive donations. A total of 143 transfusion-transmitted DENV infections probably occurred during this outbreak, accounting for 9.2 in 10 000 dengue infections. Conclusions: Approximately 0.5%-1% of blood donations were DENV RNA positive in epidemic districts. The correlation of DENV RNA rates with dengue incidence may inform the design of effective control measures. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633229 | ISSN: | 00221899 | DOI: | 10.1093/infdis/jiac014 |
顯示於: | 臨床醫學研究所 |
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