https://scholars.lib.ntu.edu.tw/handle/123456789/633230
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen, Jung-Yueh | en_US |
dc.contributor.author | Liang, Sheng-Kai | en_US |
dc.contributor.author | Chuang, Tzu-Yi | en_US |
dc.contributor.author | CHIA-YU CHU | en_US |
dc.contributor.author | Tu, Chia-Hung | en_US |
dc.contributor.author | Yeh, Yu-Jo | en_US |
dc.contributor.author | Wei, Yu-Feng | en_US |
dc.contributor.author | Chen, Kuan-Yu | en_US |
dc.date.accessioned | 2023-06-28T06:42:05Z | - |
dc.date.available | 2023-06-28T06:42:05Z | - |
dc.date.issued | 2022-09-28 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/633230 | - |
dc.description.abstract | Background Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are used as the standard first-line treatment for patients with advanced EGFR-mutated non-small cell lung cancer (NSCLC). However, the impact of clinical factors, including comorbidities and treatment-related adverse events (AEs), on quality of life (QoL) was seldom investigated. Objective We aimed to investigate the association of comorbidities, AEs, and QoL in treatment-naïve advanced NSCLC patients receiving EGFR-TKI treatments. Methods A multi-center prospective observational study was conducted to evaluate QoL and AEs at baseline, the 2nd, 4th, 12th, and 24th week. Clinical characteristics, comorbidities, and pre-treatment laboratory data were recorded. QoL was assessed by using the summary score of the EORTC QLQ-C30 and the dermatology life quality index. The impact of comorbidities, neutrophil-to-lymphocyte ratio (NLR), and AEs on QoL was analyzed by generalized estimating equations. Results A total of 121 patients were enrolled. Diarrhea (p = 0.033), anorexia (p < 0.001), and NLR ≥ 4 (p = 0.017) were significantly associated with a QoL impairment. Among skin toxicities, acneiform rash (p = 0.002), pruritus (p = 0.002), visual analogue scale for pruritus (≥ 3 and < 7, p = 0.006; ≥7, p = 0.001) and pain (1–3, p = 0.041) were associated with a QoL impairment. No significant association was found between comorbidities and QoL changes. Conclusion Diarrhea, anorexia, skin pain, and pruritus may cause a deterioration in QoL. NLR may be a potential predictive factor for QoL impairment. Aggressive management and close monitoring are crucial to improve QoL in patients receiving EGFR-TKI therapy. © 2022, CC BY. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | ResearchSquare | en_US |
dc.subject | adverse events; comorbidity; epidermal growth factor receptor tyrosine kinase inhibitor; neutrophil-to-lymphocyte ratio; non-small cell lung cancer; quality of life | en_US |
dc.title | The Impact of Comorbidities, Neutrophil-to-lymphocyte Ratio, and Adverse Events on Quality of Life in Lung Cancer Patients Receiving EGFR-TKI Therapy | en_US |
dc.type | other | en_US |
dc.identifier.doi | 10.21203/rs.3.rs-2067050 | - |
dc.identifier.scopus | 2-s2.0-85139658242 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?eid=2-s2.0-85139658242&partnerID=MN8TOARS | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_1843 | - |
item.cerifentitytype | Products | - |
item.openairetype | other | - |
item.grantfulltext | none | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology-NTUH | - |
crisitem.author.orcid | 0000-0002-9370-3279 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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