https://scholars.lib.ntu.edu.tw/handle/123456789/633476
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Kao, Yi-Chun | en_US |
dc.contributor.author | Chang, Yi-Wen | en_US |
dc.contributor.author | Lai, Charles P | en_US |
dc.contributor.author | Chang, Nai-Wen | en_US |
dc.contributor.author | Huang, Chen-Hao | en_US |
dc.contributor.author | Chen, Chien-Sheng | en_US |
dc.contributor.author | Huang, Hsuan-Cheng | en_US |
dc.contributor.author | HSUEH-FEN JUAN | en_US |
dc.date.accessioned | 2023-07-10T02:34:00Z | - |
dc.date.available | 2023-07-10T02:34:00Z | - |
dc.date.issued | 2023-06-15 | - |
dc.identifier.issn | 2399-3642 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/633476 | - |
dc.description.abstract | Ectopic ATP synthase on the plasma membrane (eATP synthase) has been found in various cancer types and is a potential target for cancer therapy. However, whether it provides a functional role in tumor progression remains unclear. Here, quantitative proteomics reveals that cancer cells under starvation stress express higher eATP synthase and enhance the production of extracellular vesicles (EVs), which are vital regulators within the tumor microenvironment. Further results show that eATP synthase generates extracellular ATP to stimulate EV secretion by enhancing P2X7 receptor-triggered Ca2+ influx. Surprisingly, eATP synthase is also located on the surface of tumor-secreted EVs. The EVs-surface eATP synthase increases the uptake of tumor-secreted EVs in Jurkat T-cells via association with Fyn, a plasma membrane protein found in immune cells. The eATP synthase-coated EVs uptake subsequently represses the proliferation and cytokine secretion of Jurkat T-cells. This study clarifies the role of eATP synthase on EV secretion and its influence on immune cells. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Nature Research | en_US |
dc.relation.ispartof | Communications biology | en_US |
dc.title | Ectopic ATP synthase stimulates the secretion of extracellular vesicles in cancer cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s42003-023-05008-5 | - |
dc.identifier.pmid | 37322056 | - |
dc.identifier.scopus | 2-s2.0-85162026894 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85162026894 | - |
dc.relation.pages | Article number 642 | en_US |
dc.relation.journalvolume | 6 | en_US |
dc.relation.journalissue | 1 | en_US |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Molecular and Cellular Biology | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.dept | Office of Research and Development | - |
crisitem.author.orcid | 0000-0003-4876-3309 | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | Administrative Unit | - |
顯示於: | 生命科學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。