https://scholars.lib.ntu.edu.tw/handle/123456789/633536
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Huang, Chi-Cheng | en_US |
dc.contributor.author | Chen, Ting-Hao | en_US |
dc.contributor.author | Liu, Liang-Chih | en_US |
dc.contributor.author | CHIUN-SHENG HUANG | en_US |
dc.contributor.author | Liang, Ji-An | en_US |
dc.contributor.author | Hsu, Yu-Chen | en_US |
dc.contributor.author | Hsieh, Chia-Ming | en_US |
dc.contributor.author | Huang, Sean-Lin | en_US |
dc.contributor.author | Shih, Kuan-Hui | en_US |
dc.contributor.author | Tseng, Ling-Ming | en_US |
dc.date.accessioned | 2023-07-12T06:11:55Z | - |
dc.date.available | 2023-07-12T06:11:55Z | - |
dc.date.issued | 2022-12-19 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/633536 | - |
dc.description.abstract | Background: A 23-gene classifier has been developed based on gene expression profiles of Taiwanese luminal-like breast cancer. We aim to stratify risk of relapse and identify patients who may benefit from adjuvant chemotherapy based on genetic model among distinct clinical risk groups. Methods: There were 248 luminal (hormone receptor-positive and human epidermal growth factor receptor II-negative) breast cancer patients with 23-gene classifier results. Using the modified Adjuvant! Online definition, clinical high/low-risk groups were tabulated with the genetic model. The primary endpoint was a recurrence-free interval (RFI) at 5 years. Results: There was a significant difference between the high/low-risk groups defined by the 23-gene classifier for the 5-year prognosis of recurrence (16 recurrences in high-risk and 3 recurrences in low-risk; log-rank test: p < 0.0001). Among the clinically high-risk group, the 5-year RFI of high risk defined by the 23-gene classifier was significantly higher than that of the low-risk group (15 recurrences in high-risk and 2 recurrences in low-risk; log-rank test: p < 0.0001). Conclusion: This study showed that 23-gene classifier can be used to stratify clinically high-risk patients into distinct survival patterns based on genomic risks and displays the potentiality to guide adjuvant chemotherapy. The 23-gene classifier can provide a better estimation of breast cancer prognosis which can help physicians make a better treatment decision. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Cancers | en_US |
dc.subject | Asian; adjuvant! online; gene expression profile; luminal type breast cancer; recurrence | en_US |
dc.title | Comparing Genetic Risk and Clinical Risk Classification in Luminal-like Breast Cancer Patients Using a 23-Gene Classifier | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/cancers14246263 | - |
dc.identifier.pmid | 36551748 | - |
dc.identifier.scopus | 2-s2.0-85144968871 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85144968871 | - |
dc.relation.journalvolume | 14 | en_US |
dc.relation.journalissue | 24 | en_US |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.orcid | 0000-0002-6557-211X | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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