https://scholars.lib.ntu.edu.tw/handle/123456789/634675
標題: | Dual-task walking improvement with enhanced kinesthetic awareness in Parkinson's disease with mild gait impairment: EEG connectivity and clinical implication | 作者: | CHENG-YA HUANG Chen, Yu-An RUEY-MEEI WU Hwang, Ing-Shiou |
關鍵字: | Parkinson’s disease; attention; beta oscillation; cortical connection; dual task; gait disorder | 公開日期: | 30-十一月-2022 | 卷: | 14 | 起(迄)頁: | 1041378 | 來源出版物: | Frontiers in aging neuroscience | 摘要: | Due to basal ganglia dysfunction, short step length is a common gait impairment in Parkinson's disease (PD), especially in a dual-task walking. Here, we use electroencephalography (EEG) functional connectivity to investigate neural mechanisms of a stride awareness strategy that could improve dual-task walking in PD. Eighteen individuals with PD who had mild gait impairment walked at self-paced speed while keeping two interlocking rings from touching each other. During the dual-task walking trial, the participants received or did not receive awareness instruction to take big steps. Gait parameters, ring-touching time, and EEG connectivity in the alpha and beta bands were analyzed. With stride awareness, individuals with PD exhibited greater gait velocity and step length, along with a significantly lower mean EEG connectivity strength in the beta band. The awareness-related changes in the EEG connectivity strength of the beta band positively correlated with the awareness-related changes in gait velocity, cadence, and step length, but negatively correlated with the awareness-related change in step-length variability. The smaller reduction in beta connectivity strength was associated with greater improvement in locomotion control with stride awareness. This study is the first to reveal that a stride awareness strategy modulates the beta band oscillatory network and is related to walking efficacy in individuals with PD in a dual-task condition. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634675 | ISSN: | 1663-4365 | DOI: | 10.3389/fnagi.2022.1041378 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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