https://scholars.lib.ntu.edu.tw/handle/123456789/634683
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHENG-YA HUANG | en_US |
dc.contributor.author | Chen, Liang-Chi | en_US |
dc.contributor.author | RUEY-MEEI WU | en_US |
dc.contributor.author | Hwang, Ing-Shiou | en_US |
dc.date.accessioned | 2023-08-25T03:31:39Z | - |
dc.date.available | 2023-08-25T03:31:39Z | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 25092715 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/634683 | - |
dc.description.abstract | Appropriate attentional resource allocation could minimize exaggerated dual-task interference due to basal ganglia dysfunction in Parkinson's disease (PD). Here, we assessed the electroencephalography (EEG) functional connectivity to investigate how task prioritization affected posture-motor dual-tasks in PD. Sixteen early-stage PD patients and 16 healthy controls maintained balance in narrow stance alone (single-posture task) or while separating two interlocking rings (postural dual-task). The participants applied a posture-focus or supraposture-focus strategy in the postural dual-task. Postural sway dynamics, ring-touching time, and scalp EEG were analyzed. Both groups exhibited smaller postural sway size, postural determinism, and ring-touching time with the supraposture-focus versus posture-focus strategy. PD patients exhibited higher mean inter-regional connectivity strength than control subjects in both single and dual-task postural conditions. To cope with dual-task interference, PD patients increased inter-regional connectivity (especially with the posture-focus strategy), while control subjects reduced inter-regional connectivity. The difference in mean connectivity strength between the dual-task condition with supraposture-focus and single-posture condition was negatively correlated to the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III total scores and hand-related sub-scores. Our findings suggest differential task prioritization effects on dual-task performance and cortical reorganization between early-stage PD and healthy individuals. Early-stage PD patients are advocated to use a supraposture-focus strategy during a postural dual-task. In addition, with a supraposture-focus strategy, PD patients with mild motor severity could increase compensatory inter-regional connectivity to cope with dual-task interference. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | GeroScience | en_US |
dc.subject | Dual-task; EEG; Functional connectivity; Parkinson’s disease; Task prioritization | en_US |
dc.title | Effects of task prioritization on a postural-motor task in early-stage Parkinson's disease: EEG connectivity and clinical implication | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1007/s11357-022-00516-4 | - |
dc.identifier.pmid | 35039998 | - |
dc.identifier.scopus | 2-s2.0-85123090784 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/594100 | - |
dc.relation.pages | 2061 | en_US |
dc.relation.journalvolume | 44 | en_US |
dc.relation.journalissue | 4 | en_US |
dc.relation.pageend | 2075 | en_US |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Physical Therapy | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Clinical Center for Neuroscience and Behavior | - |
crisitem.author.dept | Psychology | - |
crisitem.author.orcid | 0000-0001-6946-2105 | - |
crisitem.author.orcid | 0000-0002-4947-5467 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Science | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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