https://scholars.lib.ntu.edu.tw/handle/123456789/637255
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin, Yi Ling | en_US |
dc.contributor.author | Lu, Ching Fu | en_US |
dc.contributor.author | Wu, Yi Hsieng Samuel | en_US |
dc.contributor.author | Yang, Kuo Tai | en_US |
dc.contributor.author | WEN-YUAN YANG | en_US |
dc.contributor.author | Chen, Jr Wei | en_US |
dc.contributor.author | Tseng, Jung Kai | en_US |
dc.contributor.author | Chen, Yi Chen | en_US |
dc.date.accessioned | 2023-11-20T07:39:13Z | - |
dc.date.available | 2023-11-20T07:39:13Z | - |
dc.date.issued | 2021-08-01 | - |
dc.identifier.issn | 00325791 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/637255 | - |
dc.description.abstract | Four-hundred metric-ton chalazae are produced annually from the liquid-egg processing and always cause a heavy burden due to handling cost in Taiwan. After chalazae were hydrolyzed by protease A, the amounts of hydrophobic, aromatic, and branched-chain amino acids, as well as anserine were dramatically increased. This study was to understand the antifibrogenic effects of protease A-digested crude chalaza hydrolysates (CCH-As) on livers of thioacetamide (TAA) treated rats. CCH-As improved (P< 0.05) growth performance, serum liver damage indices, histopathological liver inflammation, and liver collagen deposition in TAA-treated rats. The antifibrogenic effects of CCH-As were due to decreased (P < 0.05) inflammatory/fibrogenic cytokine contents, α-smooth-muscle-actin (α-SMA) protein expression, and matrix metallopeptidase (MMP)-2 and -9 activities, as well as increased (P < 0.05) the antioxidant capacity in livers. CCH-As also increased (P < 0.05) cleaved caspase-3 and cleaved poly ADP-ribose polymerase protein levels in livers of TAA-treated rats which accelerating cell renewal. Thus, this study does not only reveal a novel nutraceutical ingredient, CCH-As, against liver fibrogenesis, but also offer an alternative way to expand the utilization of poultry byproducts. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Poultry Science | en_US |
dc.subject | anti-inflammation | antioxidant | apoptosis | crude chalaza hydrolysates | liver fibrosis | en_US |
dc.title | Protective effects of crude chalaza hydrolysates against liver fibrogenesis via antioxidation, anti-inflammation/anti-fibrogenesis, and apoptosis promotion of damaged hepatocytes | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.psj.2021.101175 | - |
dc.identifier.pmid | 34175800 | - |
dc.identifier.scopus | 2-s2.0-85108608394 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85108608394 | - |
dc.relation.journalvolume | 100 | en_US |
dc.relation.journalissue | 8 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Veterinary Medicine | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 獸醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。