https://scholars.lib.ntu.edu.tw/handle/123456789/637337
標題: | High-fat diet induces C-reactive protein secretion, promoting lung adenocarcinoma via immune microenvironment modulation | 作者: | Hsu, Wei-Lun Hsieh, Yun-Ting Chen, Wei-Ming Chien, Min-Hui Luo, Wei-Jia Chang, Jung-Hsuan Devlin, Kevin KANG-YI SU |
關鍵字: | CRP; High-fat diet; Lung cancer; Mutant EGFR transgenic mice; Tumor microenvironment | 公開日期: | 1-十一月-2023 | 卷: | 16 | 期: | 11 | 來源出版物: | Disease models & mechanisms | 摘要: | To understand the effects of a high-fat diet (HFD) on lung cancer progression and biomarkers, we here used an inducible mutant epidermal growth factor receptor (EGFR)-driven lung cancer transgenic mouse model fed a regular diet (RD) or HFD. The HFD lung cancer (LC-HFD) group exhibited significant tumor formation and deterioration, such as higher EGFR activity and proliferation marker expression, compared with the RD lung cancer (LC-RD) group. Transcriptomic analysis of the lung tissues revealed that the significantly changed genes in the LC-HFD group were highly enriched in immune-related signaling pathways, suggesting that an HFD alters the immune microenvironment to promote tumor growth. Cytokine and adipokine arrays combined with a comprehensive analysis using meta-database software indicated upregulation of C-reactive protein (CRP) in the LC-HFD group, which presented with increased lung cancer proliferation and metastasis; this was confirmed experimentally. Our results imply that an HFD can turn the tumor growth environment into an immune-related pro-tumorigenic microenvironment and demonstrate that CRP has a role in promoting lung cancer development in this microenvironment. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637337 | ISSN: | 1754-8403 1754-8411 |
DOI: | 10.1242/dmm.050360 |
顯示於: | 醫學檢驗暨生物技術學系 |
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