https://scholars.lib.ntu.edu.tw/handle/123456789/637363
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shiota, Tomoyuki | en_US |
dc.contributor.author | Li, Zhucui | en_US |
dc.contributor.author | GUAN-YUAN CHEN | en_US |
dc.contributor.author | McKnight, Kevin L | en_US |
dc.contributor.author | Shirasaki, Takayoshi | en_US |
dc.contributor.author | Yonish, Bryan | en_US |
dc.contributor.author | Kim, Heyjeong | en_US |
dc.contributor.author | Fritch, Ethan J | en_US |
dc.contributor.author | Sheahan, Timothy P | en_US |
dc.contributor.author | Muramatsu, Masamichi | en_US |
dc.contributor.author | Kapustina, Maryna | en_US |
dc.contributor.author | Cameron, Craig E | en_US |
dc.contributor.author | Li, You | en_US |
dc.contributor.author | Zhang, Qibin | en_US |
dc.contributor.author | Lemon, Stanley M | en_US |
dc.date.accessioned | 2023-11-24T06:48:26Z | - |
dc.date.available | 2023-11-24T06:48:26Z | - |
dc.date.issued | 2023-10-20 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/637363 | - |
dc.description.abstract | Virus-induced changes in host lipid metabolism are an important but poorly understood aspect of viral pathogenesis. By combining nontargeted lipidomics analyses of infected cells and purified extracellular quasi-enveloped virions with high-throughput RNA sequencing and genetic depletion studies, we show that hepatitis A virus, an hepatotropic picornavirus, broadly manipulates the host cell lipid environment, enhancing synthesis of ceramides and other sphingolipids and transcriptionally activating acyl-coenzyme A synthetases and fatty acid elongases to import and activate long-chain fatty acids for entry into the fatty acid elongation cycle. Phospholipids with very-long-chain acyl tails (>C22) are essential for genome replication, whereas increases in sphingolipids support assembly and release of quasi-enveloped virions wrapped in membranes highly enriched for sphingomyelin and very-long-chain ceramides. Our data provide insight into how a pathogenic virus alters lipid flux in infected hepatocytes and demonstrate a distinction between lipid species required for viral RNA synthesis versus nonlytic quasi-enveloped virus release. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Science advances | en_US |
dc.title | Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1126/sciadv.adj4198 | - |
dc.identifier.pmid | 37862421 | - |
dc.identifier.scopus | 2-s2.0-85175660250 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85175660250 | - |
dc.relation.journalvolume | 9 | en_US |
dc.relation.journalissue | 42 | en_US |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Forensic Medicine | - |
crisitem.author.orcid | 0000-0002-0505-4089 | - |
crisitem.author.parentorg | College of Medicine | - |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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