DC 欄位 | 值 | 語言 |
dc.contributor | 陳延平 | zh-TW |
dc.contributor | Chen, Yan-Ping | en |
dc.contributor | 臺灣大學:化學工程學研究所 | zh-TW |
dc.contributor.author | 陳志清 | zh-TW |
dc.contributor.author | Chen, Chi-Ching | en |
dc.creator | 陳志清 | zh-TW |
dc.creator | Chen, Chi-Ching | en |
dc.date | 2009 | en |
dc.date.accessioned | 2010-06-30T06:29:21Z | - |
dc.date.accessioned | 2018-06-28T17:17:11Z | - |
dc.date.available | 2010-06-30T06:29:21Z | - |
dc.date.available | 2018-06-28T17:17:11Z | - |
dc.date.issued | 2009 | - |
dc.identifier.other | U0001-0607200913001400 | en |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/187008 | - |
dc.description.abstract | 智慧型高分子目前被廣泛的應用於各個研究領域,其中pH值敏感性及溫度敏感性材料可應用於藥物控制釋放和生物科技材料上,此材料本身如果具備生物可分解性,將更增加其應用價值,本研究選擇之溫度敏感性材料poly[(2-(2-methoxyethoxy)ethyl methacrylate)-co-(oligo(ethylene glycol) methacrylate)] [P(MEO2MA-co-OEGMA)]和pH值敏感性材料[(polydimethylsiloxane)-g-(polyacrylate)] (PDSM-g-PAA)皆具有相當好的生物可分解性,而且此溫度敏感性材料可藉由改變組成調整低臨界溶解溫度(lower critical solution temperature, LCST)值,增加材料的應用性。一般合成方法所使用的有機溶劑、觸媒和起始劑對於環境有較大的衝擊性,並且會造成後續產物分離程序上的困難,因此本研究利用超臨界二氧化碳技術進行此溫度敏感性材料的合成,並進一步加入pH值敏感性材料與其交聯,提高材料之功能性。 本研究結果顯示在超臨界二氧化碳系統下的確可以合成此溫度敏感性材料,並且經由UV分析後,確認此材料可藉由組成不同而改變LCST值。在進一步加入pH值敏感性材料後,也可由FTIR、TGA、TEM、UV等儀器分析以及膨潤度(swelling ratio)測試,確認兩材料的確有產生交聯,結構上具有core-shell的型態,並且敏感性顯示在溫度35℃以上和pH值7以上會產生明顯的狀態變化;製程上,亦可經由簡單的洩壓得到乾燥的產物,簡化分離程序,同時有機溶劑的使用量大幅減少,有效降低對環境的汙染性。另一方面,本研究亦針對操作參數對於產物分結構、粒徑大小、顆粒分散性以及對溫度和pH值的敏感性進行分析,決定最佳的操作條件為壓力300bar,溫度100℃,反應時間4小時,反應物組成為60wt%的PDMS-g-PAA。從SEM圖中觀察到原本不規則片狀的PDMS-g-PAA顆粒經由此反應程序可合成接近球狀的(PDMS-g-PAA)-g-P(MEO2MA-co-OEGMA),進一步利用imageJ軟體分析圖中顆粒大小後,發現PDMS-g-PAA原始粒徑為11μm,反應後產物粒徑最小可降至0.15μm。 | zh-TW |
dc.description.abstract | The supercritical carbon dioxide is applied in this research to synthesize the temperature/pH value sensitive biodegradable core-shell smart copolymer materials. Supercritical fluid technology has the advantages of reducing significantly the amount of solvent in traditional process. It can also avoid the oxidation of initiators, and simplify the following separation steps. The dry products can be obtained after depressurization and the desired smart copolymer material is used for the controlled release of drugs, or the phase separation for protein recovery. In this study, poly[(2-(2-methoxyethoxy)ethyl methacrylate)-co-(oligo(ethylene glycol) methacrylate)] [P(MEO2MA-co-OEGMA)] with great temperature-sensitive properties was synthesized by polymerization reaction in the medium of supercritical carbon dioxide (scCO2). Its LCST (lower critical solution temperature) value was changed by adjusting the compositions of monomers. Furthermore, the copolymers with fine temperature- and pH-sensitive properties have been obtained through the single step supercritical carbon dioxide chemical reaction process for the polymerization of temperature-sensitive material and cross-linking with the [(polydimethylsiloxane)-graft-(polyacrylate)] (PDMS-g-PAA). The particles transform between swelling and shrinking with the temperature and pH value limits of 35℃and 7, respectively. The core-shell structure was observed by TEM images. The characteristics of the products were examined using UV, FTIR, TGA, SEM, and swelling ratio analysis. The optimal process parameters in the synthesis of smart core-shell copolymers were reported in this study. The particles with great pH/T-sensitive properties, smaller average particle size and size distribution were obtained at the following operating condition: T=100℃, P=300bar, Reaction Time=4hr, Reactants composition=60wt% PDMS-g-PAA. From SEM images and the analysis of image J software, we observed the morphology of original PDMS-g-PAA particle was amorphous with an approximately particle size = 11μm . After reaction process, the grafted copolymer particle became globular shape. The particle size was reduced to 0.15μm. | en |
dc.description.tableofcontents | 口試委員審定書 I謝 II文摘要 III文摘要 V錄 VII目錄 X目錄 XIV一章 緒論 1 1-1超臨界流體(Supercritical Fulid, SCF)的簡介 1 1-2超臨界流體反應(SCF Reaction)的簡介 2 1-2-1超臨界流體反應的應用 3二章 文獻回顧 6 2-1複合材料的簡介 6 2-1-1智慧型複合材料的介紹 7 2-1-2智慧型複合材料的合成方法 7 2-1-3智慧型材料在藥物控制釋放和生物蛋白質技術上的應用 9 2-2溫度敏感性材料的簡介 11 2-2-1替代性溫度敏感性材料的介紹 12 2-3 pH值敏感性材料的簡介 14 2-3-1pH值敏感性材料的種類 14 2-3-2pH值敏感性材料的優點 15 2-4 pH值及溫度敏感性材料的共聚物介紹 162-5研究目的 17三章 實驗方法與步驟 20 3-1實驗藥品與儀器 20 3-1-1實驗藥品 20 3-1-2實驗儀器 22 3-1-3實驗分析儀器 22 3-2實驗裝置 25 3-3實驗步驟 26 3-3-1溫度敏感性材料P(MEO2MA-co-OEGMA)的合成實驗 26 3-3-2 pH值敏感性和溫度敏感性共聚物 27 (PDMS-g-PAA)-g-P(MEO2MA-co-OEGMA)的合成實驗 3-4分析方法 29 3-4-1結構分析 29 3-4-2外觀形狀及顆粒大小分析 29 3-4-3溫度敏感性及pH值敏感性分析 30 3-4-4產物回收率計算 32四章 實驗結果與討論 33 4-1利用超臨界二氧化碳合成Poly(MEO2MA-co-OEGMA)的結果與討論 33 4-1-1反應機制與結構變化的討論 33 4-1-2 Poly(MEO2MA-co-OEGMA)的FTIR分析 34 4-1-3 Poly(MEO2MA-co-OEGMA)的溫度敏感性分析 35 4-1-4 Poly(MEO2MA-co-OEGMA)的裂解溫度和含水性分析 38 4-2利用超臨界二氧化碳合成(PDMS-g-PAA)-g- 38 P(MEO2MA-co-OEGMA)的結果與討論 4-2-1 交聯反應機制與結構變化的討論 39 4-2-2 (PDMS-g-PAA)-g-P(MEO2MA-co-OEGMA)的FTIR分析 39 4-2-3 (PDMS-g-PAA)-g-P(MEO2MA-co-OEGMA)的TGA分析 40 4-2-4 (PDMS-g-PAA)-g-P(MEO2MA-co-OEGMA)的TEM分析 41 4-2-5 (PDMS-g-PAA)-g-P(MEO2MA-co-OEGMA)的溫度敏感性分析 42 4-2-6 (PDMS-g-PAA)-g-P(MEO2MA-co-OEGMA)的pH值敏感性分析 43 4-3實驗參數對(PDMS-g-PAA)-g-P(MEO2MA-co-OEGMA)性質的影響 43 4-3-1 反應溫度的影響 43 4-3-2 反應壓力的影響 46 4-3-3 反應時間的影響 47 4-3-4 反應物組成的影響 49五章 結論 52考文獻 99 | en |
dc.format.extent | 4746317 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | zh-TW | en |
dc.language.iso | en_US | - |
dc.subject | 超臨界二氧化碳 | zh-TW |
dc.subject | pH值敏感性 | zh-TW |
dc.subject | 溫度敏感性 | zh-TW |
dc.subject | 水凝膠 | zh-TW |
dc.subject | 核殼共聚物 | zh-TW |
dc.subject | supercritical carbon dioxide | en |
dc.subject | pH-sensitive | en |
dc.subject | temperature-sensitive | en |
dc.subject | hydrogel | en |
dc.subject | core-shell | en |
dc.subject | smart material | en |
dc.subject | LCST | en |
dc.title | 利用超臨界二氧化碳製備生物可分解之溫度/pH敏感性核殼共聚物 | zh-TW |
dc.title | Synthesis of Biodegradable Thermo/pH-Sensitive Core-Shell Copolymer in Supercritical CO2 | en |
dc.type | thesis | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/187008/1/ntu-98-R96524020-1.pdf | - |
item.openairecristype | http://purl.org/coar/resource_type/c_46ec | - |
item.openairetype | thesis | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
顯示於: | 化學工程學系
|