https://scholars.lib.ntu.edu.tw/handle/123456789/637981
Title: | A short peptide derived from pigment epithelial-derived factor exhibits an angioinhibitory effect | Authors: | Ho, Tsung-Chuan Yeh, Shu-I SHOW-LI CHEN Chu, Ting-Wen Tsao, Yeou-Ping |
Keywords: | Apoptosis; Corneal neovascularization; Peptide; Pigment epithelial-derived factor; Vascular endothelial growth factor | Issue Date: | 22-Feb-2022 | Journal Volume: | 22 | Journal Issue: | 1 | Source: | BMC ophthalmology | Abstract: | Pigment epithelial-derived factor (PEDF), a 50 kDa secreted glycoprotein, exhibits distinct effects on a range of cell types. PEDF has been shown to inhibit vascular endothelial growth factor (VEGF)-mediated angiogenesis and widely accepted as a promising agent for treatment eye diseases related to neovascularization. A pool of short peptide fragments derived from PEDF reportedly manifests angioinhibitory activity. This study aims to determine the minimal PEDF fragment which can exert the anti-VEGF effect. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637981 | ISSN: | 1471-2415 | DOI: | 10.1186/s12886-022-02295-0 |
Appears in Collections: | 微生物學科所 |
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