https://scholars.lib.ntu.edu.tw/handle/123456789/638307
DC Field | Value | Language |
---|---|---|
dc.contributor.author | DA-LIANG OU | en_US |
dc.contributor.author | Liao, Zi-Xian | en_US |
dc.contributor.author | Kempson, Ivan M | en_US |
dc.contributor.author | Li, Lin | en_US |
dc.contributor.author | PAN-CHYR YANG | en_US |
dc.contributor.author | Tseng, S-Ja | en_US |
dc.date.accessioned | 2024-01-09T05:48:01Z | - |
dc.date.available | 2024-01-09T05:48:01Z | - |
dc.date.issued | 2024-01-02 | - |
dc.identifier.issn | 10217770 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/638307 | - |
dc.description.abstract | As of 2020, hepatocellular carcinoma (HCC), a form of liver cancer, stood as the third most prominent contributor to global cancer-related mortality. Combining immune checkpoint inhibitors (ICI) with other therapies has shown promising results for treating unresectable HCC, offering new opportunities. Recombinant adeno-associated viral type 2 (AAV2) virotherapy has been approved for clinical use but it efficacy is stifled through systemic administration. On the other hand, iron oxide nanoparticles (ION) can be cleared via the liver and enhance macrophage polarization, promoting infiltration of CD8+ T cells and creating a more favorable tumor microenvironment for immunotherapy. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of biomedical science | en_US |
dc.subject | Adeno-associated virus; Immune-promoting effect; Iron oxide nanoparticles; Macrophage; Orthotopic hepatocellular carcinoma; Photodynamic virotherapy | en_US |
dc.title | Nano-modified viruses prime the tumor microenvironment and promote the photodynamic virotherapy in liver cancer | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1186/s12929-023-00989-1 | - |
dc.identifier.pmid | 38163894 | - |
dc.identifier.scopus | 2-s2.0-85181227761 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85181227761 | - |
dc.relation.journalvolume | 31 | en_US |
dc.relation.journalissue | 1 | en_US |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-8368-1141 | - |
crisitem.author.orcid | 0000-0001-6330-6048 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 腫瘤醫學研究所 |
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