https://scholars.lib.ntu.edu.tw/handle/123456789/639811
Title: | Exploring the multifaceted impact of lanthanides on physiological pathways in human breast cancer cells | Authors: | Huang, Yi-Ming Hsu, Tsu-Yu Liu, Ching-Yu Hsieh, Yu-Chen Lai, Kuan-Yun Yang, Ya-Wen KAI-YIN LO |
Keywords: | Cytoskeleton assembly; Lanthanides; Nucleolar stress; Protein homeostasis; Triple-negative breast cancer | Issue Date: | Feb-2024 | Journal Volume: | 502 | Source: | Toxicology | Abstract: | Lanthanum (La) and cerium (Ce), rare earth elements with physical properties similar to calcium (Ca), are generally considered non-toxic when used appropriately. However, their ions possess anti-tumor capabilities. This investigation explores the potential applications and mechanisms of LaCl3 or CeCl3 treatment in triple-negative breast cancer (TNBC) cell lines. TNBC, characterized by the absence of estrogen receptor (ERα), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression, is prone to early metastasis and resistant to hormone therapy. Our results demonstrate that La/Ce treatment reduces cell growth, and when combined with cisplatin, it synergistically inhibits cell growth and the PI3K/AKT pathway. La and Ce induce oxidative stress by disrupting mitochondrial function, leading to protein oxidation. Additionally, they interfere with protein homeostasis and induce nucleolar stress. Furthermore, disturbance in F-actin web formation impairs cell migration. This study delves into the mechanism by which calcium-like elements La and Ce inhibit breast cancer cell growth, shedding light on their interference in mitochondrial function, protein homeostasis, and cytoskeleton assembly. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639811 | ISSN: | 0300483X | DOI: | 10.1016/j.tox.2024.153731 |
Appears in Collections: | 農業化學系 |
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