https://scholars.lib.ntu.edu.tw/handle/123456789/640728
Title: | The Critical Role of Equilibrative Nucleoside Transporter-2 in Modulating Cerebral Damage and Vascular Dysfunction in Mice with Brain Ischemia-Reperfusion | Authors: | Chiang, Hui-Ling Wu, Kuo-Chen Chen, You-Yin Ho, Chin-Jui Wang, Han-Lin Fu, Yu-Hua Chen, Wen-Yu CHUN-JUNG LIN |
Keywords: | adenosine; blood-brain barrier; equilibrative nucleoside transporters; ischemia-reperfusion injury; neuroinflammation | Issue Date: | Nov-2023 | Journal Volume: | 40 | Journal Issue: | 11 | Start page/Pages: | 2541 | Source: | Pharmaceutical research | Abstract: | Cerebral vascular protection is critical for stroke treatment. Adenosine modulates vascular flow and exhibits neuroprotective effects, in which brain extracellular concentration of adenosine is dramatically increased during ischemic events and ischemia-reperfusion. Since the equilibrative nucleoside transporter-2 (Ent2) is important in regulating brain adenosine homeostasis, the present study aimed to investigate the role of Ent2 in mice with cerebral ischemia-reperfusion. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/640728 | ISSN: | 07248741 | DOI: | 10.1007/s11095-023-03565-2 |
Appears in Collections: | 藥學系 |
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