https://scholars.lib.ntu.edu.tw/handle/123456789/641774
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu, Jui-Hsuan | en_US |
dc.contributor.author | Lee, Jen-Chi | en_US |
dc.contributor.author | Ho, Chun-Che | en_US |
dc.contributor.author | Chiu, Pei-Wei | en_US |
dc.contributor.author | CHIN-HUNG SUN | en_US |
dc.date.accessioned | 2024-04-08T07:29:56Z | - |
dc.date.available | 2024-04-08T07:29:56Z | - |
dc.date.issued | 2023-04-24 | - |
dc.identifier.issn | 1745-6150 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/641774 | - |
dc.description.abstract | The eukaryotic membrane vesicles contain specific sets of proteins that determine vesicle function and shuttle with specific destination. Giardia lamblia contains unknown cytosolic vesicles that are related to the identification of a homolog of human myeloid leukemia factor (MLF) named MLF vesicles (MLFVs). Previous studies suggest that MLF also colocalized with two autophagy machineries, FYVE and ATG8-like protein, and that MLFVs are stress-induced compartments for substrates of the proteasome or autophagy in response to rapamycin, MG132, and chloroquine treatment. A mutant protein of cyclin-dependent kinase 2, CDK2m3, was used to understand whether the aberrant proteins are targeted to degradative compratments. Interestingly, MLF was upregulated by CDK2m3 and they both colocalized within the same vesicles. Autophagy is a self-digestion process that is activated to remove damaged proteins for preventing cell death in response to various stresses. Because of the absence of some autophagy machineries, the mechanism of autophagy is unclear in G. lamblia. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Biology direct | en_US |
dc.subject | ATG8-like; CDK2 mutant; Cyst; DTT; Differentiation; FYVE; G418; Giardia; MLF; Nocodazole | en_US |
dc.title | A myeloid leukemia factor homolog is involved in tolerance to stresses and stress-induced protein metabolism in Giardia lamblia | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1186/s13062-023-00378-6 | - |
dc.identifier.pmid | 37095576 | - |
dc.identifier.scopus | 2-s2.0-85153686892 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85153686892 | - |
dc.relation.journalvolume | 18 | en_US |
dc.relation.journalissue | 1 | en_US |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Tropical Medicine and Parasitology | - |
crisitem.author.orcid | 0000-0002-8604-8085 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 熱帶醫學暨寄生蟲學科 |
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