Project title
綠豆殼萃取物作為寵物抗病毒製劑之功效性評估
Internal ID
MOST109-2321-B002-033
Principal Investigator
Start Date
June 1, 2021
End Date
May 31, 2022
Organizations
Partner Organizations
綠豆殼萃取物作為寵物抗病毒製劑之功效性評估=Development of Antiviral Drugs for Companion Animals from the Mung Bean Seed Coat Extract
Keywords
Vigna radiata extract
feline coronavirus
parrot bornavirus
antivirals
Description
Our previous study has confirmed that Vigna radiata extract (VRE) has multiple antiviral mechanisms and can effectively inhibit three poultry respiratory viruses including the influenza virus. This study intends to evaluate and develop potent antiviral drugs against the feline coronavirus (FCoV) and parrot bornavirus (PaBV), which are lethal pathogens for feline and psittacine species, respectively. Cellular experiments were conducted and the cytotoxicity of VRE in Fcwf-4 cells and QM7 cells were determined. The results showed that VRE has dose-dependent antiviral activity against FCoV and PaBV. Furthermore, the time of addition assay was performed to find out the best treatment conditions and the antiviral mechanisms. This study investigated the inhibitory effect of mung bean extract, a product of the circular economy, on cell infection by two viruses that endanger pet health, and has the potential to develop innovative antiviral biologics to improve animal health.