Applications of Metallic Nanoparticles on Surface-Enhanced Raman Scattering and Bio-sensor
Date Issued
2011
Date
2011
Author(s)
Lin, Yu-Syuan
Abstract
Surface-enhanced Raman scattering technique can detect molecules of low concentrations, so many groups are dedicated to study different metallic nanostructures and hope to improve the sensitivity even to single-molecule level. However, it is time-consuming and high-cost to manufacture the special structure and the detection usually performs poor repeatability. In the first part of this thesis, we use the FDTD method to simulate the localized electronic field and expected surface enhanced Raman scattering effect of gold nanospheres under different area coverage and diameters. Besides, we use design experiment to prove the results from related simulations, which compares the effect of hot spots’ numbers and intensity on the SERS signal. In the second part of this thesis, we use seed-mediated growth method to synthesize the gold nanorods. And we first place the gold nanospheres on the silicon substrate by binding agent. Then, we use polymer with appropriate end functional group to form nanorods layers on top the gold nanospheres layer. By ellipseometric measurement, we can observe the electromagnetic coupling between the gold nanospheres and the nanorods. We construct the multilayer optical thin film model to fit the optical constant. Furthermore, we take advantages of the high-sensitivity of gold nanorods to produce the bio-sensor and detect the molecules by ellipsometric measurement, and hope to obtain an optoelectronic bio-sensor with high sensitivity.
Subjects
Surface-enhanced Raman scattering
three dimensional finite-difference time-domain
seed-mediated growth
ellipseometric
metallic nanoparticles
Type
thesis
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