https://scholars.lib.ntu.edu.tw/handle/123456789/78765
標題: | Implications of human pharmaceutical occurrence in the Sindian river of Taiwan: A strategic study of risk assessment | 作者: | Lin, Angela Yu-Chen Panchangam, Sri Chandana Chen, Huan-Yo |
公開日期: | 2010 | 起(迄)頁: | 261-270 | 來源出版物: | Journal of Environmental Monitoring | 摘要: | Contamination of natural aquatic environments with human-use pharmaceuticals poses a significant potential threat to local ecosystems. However studies of the risk assessment of this contamination are limited, in part because currently the environmental concentration prediction is logistically and technically difficult to perform. In this study, 1) a strategic method to determine occurrence and risk of pharmaceutical compounds in an aquatic environment is proposed, and 2) this method is applied to study ten human-use pharmaceuticals in Taiwan's Sindian river, which traverses and supplies drinking water for Taipei, a major metropolitan center. In river-water samples collected over a three-week period, concentrations of NSAIDs (acetaminophen, diclofenac, ibuprofen, naproxen, and ketoprofen), steroids (estrone, 17α-ethinylestradiol and 17β-estradiol), the anti-hypertensive agent propranolol, and the lipid regulator gemfibrozil were found at ng/L to μg/L levels; night-time concentrations were often doubled or even greater, compared to day-time levels. With the exception of the estrogens, predicted environmental concentrations (PECs) of the target pharmaceuticals agreed well with measured environmental concentrations (MECs). Conclusions: In the Sindian river, which is impacted by both regional and hospital discharges, the pattern of pharmaceutical occurrences and concentrations observed here is due to variations in source release rather than to natural attenuation phenomena. In addition, the environmental risk posed by acetaminophen, ibuprofen, and the estrogens was observed to be imminent, while risk from the other drugs targeted was found to be lower, even when maximum MECs were considered. © 2010 The Royal Society of Chemistry. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/242757 | DOI: | 10.1039/b903880a | SDG/關鍵字: | diclofenac; drinking water; estradiol; estrogen; estrone; ethinylestradiol; gemfibrozil; ibuprofen; ketoprofen; naproxen; paracetamol; propranolol; river water; aquatic environment; article; concentration (parameters); environmental factor; liquid chromatography; physical chemistry; priority journal; risk assessment; Taiwan; tandem mass spectrometry; time; water analysis; water contamination; water sampling; water supply; Anti-Inflammatory Agents, Non-Steroidal; Cities; Environmental Monitoring; Humans; Pharmaceutical Preparations; Risk Assessment; Rivers; Steroids; Taiwan; Time Factors; Waste Disposal, Fluid; Water Pollutants, Chemical |
顯示於: | 環境工程學研究所 |
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