https://scholars.lib.ntu.edu.tw/handle/123456789/79898
Title: | Surface ultrastructure of SARS coronavirus revealed by atomic force microscopy | Authors: | SHI-MING LIN CHIH-KUNG LEE Lee S.-Y. CHUAN-LIANG KAO CHII-WANN LIN AN-BANG WANG Hsu S.-M. Huang L.-S. |
Issue Date: | 2005 | Journal Volume: | 7 | Journal Issue: | 12 | Start page/Pages: | 1763-1770 | Source: | Cellular Microbiology | Abstract: | Atomic force microscopy has been used to probe the surface nanostructures of severe acute respiratory syndrome coronavirus (SARS-CoV). Single crown-like virion was directly visualized and quantitative measurements of the dimensions for the structural proteins were provided. A corona of large, distinctive spikes in the envelope was measured after treatment with hydroxyoctanoic acid. High-resolution images revealed that the surface of each single SARS-CoV was surrounded with at least 15 spherical spikes having a diameter of 7.29 ± 0.73 nm, which is in close agreement with that of S glycoproteins earlier predicted through the genomes of SARS-CoV. This study represents the first direct characterization of the surface ultrastructures of SARS-CoV particles at the nanometre scale and offers new prospects for mapping viral surface properties. © 2005 Blackwell Publishing Ltd. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/107061 http://ntur.lib.ntu.edu.tw/bitstream/246246/107061/1/16.pdf https://www.scopus.com/inward/record.uri?eid=2-s2.0-28044445658&doi=10.1111%2fj.1462-5822.2005.00593.x&partnerID=40&md5=9634732d574da92007ee988573046cca |
DOI: | 10.1111/j.1462-5822.2005.00593.x |
Appears in Collections: | 應用力學研究所 |
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