A Rapid Micromixer via 3D Counter-Rotating Circulatory Flow
Date Issued
2008
Date
2008
Author(s)
Liu, Hsin-Ping
Abstract
This work presents an ultra-fast micromixer via a pair of 3D, counter-rotating, circulatory flow structure. This feature is secondary steady streaming induced by a resonating gold-coated suspended structure, consisting of two long beams (400um length) supporting a microplate (100um × 200um) at the center. As AC current passes through this structure, an external magnet placed underneath forcing the microplate to in-plane resonance as result of Lorentz law. Two heterogeneous streams passes the 3D circulatory flow results in a mixing efficiency increase of 72% within 900μm mixing length, under background flow speed of 36.4mm/s, Pèclet number of 6.61×104, Reynold’s number of 1.72. For background flow speed of 10mm/s and 5mm/s, 71% and 56% of increase mixing efficiency under same mixing length of 900μm, implies a mixing efficiency independent of Reynold’s number. Application of the device to enhance lysis of erythrocytes is made by in-flowing of the cells in one stream and lysis solution in another. Results showed a 68% lysis rate could be obtained within 1cm mixing length, where as only 0.7% for a straight channel. Furthermore, lysis rate could be controlled by excited AC voltage on the oscillating plate according to results obtained, which could provide an environment for erythrocyte lysis and prevent stress target cells for extended period in macroscale isolation, which could avoid differentiations caused by manual manipulation.
Subjects
Lorentz force
counter-rotating micro-vortices
erythrocyte lysis
Type
thesis
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