Theoretical Investigations and Numerical Simulations for Micromixers and Resonant Microcantilever-Based Biosensors
Date Issued
2011
Date
2011
Author(s)
Huang, Kuan-Rong
Abstract
In the last two decades, micromixers and biosensors in the micro system are popularly investigated and developed. A micromixer is primarily employed for mixing fluids by means of externally or internally mechanical mechanisms. A biosensor is based on several advantages, such as highly sensitive, tiny mass load detection and capable of monitoring dynamic biomolecular interaction in real time, to be used as the apparatus for the biomolecule detection.
Then, the study of AC electrokinetics is correlated with the motion behavior of particles in fluids, and it is also widely applied on microfluidic devices in the recent decade. When microfluidic devices of the microfabricated electrode systems are subjected to AC electrical fields, the AC electrokinetics involving the dielectrophoresis, AC electroosmosis or AC electrothermal force will be generated according to charges of colloids, different properties of electrolytes or amplitude and frequency of external applied voltages.
This thesis is divided into three major subjects: micromixers, resonant microcantilever-based biosensors, and immunoassay of the biosensor. In terms of AC electrokinetics: AC electrothermal force, micromixers and immunoassay of the biosensor will be concentrated on meliorating their working efficiency by employing finite element method. For resonant microcantilever-based biosensors, a comprehensive investigation will be theoretically and numerically executed, involving the study of fundamental vibrational properties, the sensitivity of resonant microcantilever-based biosensors, and a comparison of distinct resonant biosensors, etc. Target components comprise as follows: micorcantilever beam sensor (MCB), microcantilever beam array sensor, suspended microchannel resonator (SMR), quartz crystal micorbalance (QCM).
Subjects
micromixer
microcantilever-based biosensor
microcantilever beam array
suspended microchannel resonator
quartz crystal micorbalance
immunoassay
AC electrokinetics
dielectrophoresis
AC electroosmosis
AC electrothermal force
finite element method
Type
thesis
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