Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Engineering / 工學院
  3. Applied Mechanics / 應用力學研究所
  4. Improving an Impedance Biosensor System Design by Studying the Charge Transfer Resistance Mechanism
 
  • Details

Improving an Impedance Biosensor System Design by Studying the Charge Transfer Resistance Mechanism

Date Issued
2011
Date
2011
Author(s)
Chen, Ying-Hua
URI
http://ntur.lib.ntu.edu.tw//handle/246246/249950
Abstract
Electrochemical impedance spectroscopy (EIS) has been widely used in many applications such as biosensors over these decades. For the development of electrochemical sensor, the condition and property of electrode surface play a crucial role. The factors of how the surface property affects the electrochemical response have been studied for years; however, a more detailed research of the mechanism is still required. In a faradaic EIS, a Randles model is often used to fit the measured impedance data and the circuit element of charge transfer resistance (Rct) dedicates the most of the impedance change. Apart from the energy potential of the redox pair, steric hindrance and electrostatic force are the two well-known factors responsible for the Rct change. To further investigate how these two factors affect the Rct element, we used conductive atomic force microscopy (CAFM), zeta potential measurements and electrochemical method as tools. In this study, 7 kinds of conductive linkers and a conventional alkanethiol linker were used to form the self-assembled monolayers (SAMs) on the gold electrode. From the experimental results, it can be found that the Rct increases logarithmically with monolayer resistance, and decreases exponentially with the surface charge. This result indicates that the steric hindrance plays a minor role in the Rct change when compared to that of the electrostatic force. By this understanding, we can design a low impedance linker to enhance the signal-to-noise ratio. This enhanced signal can also improve the sensor sensitivity and detection limit. Here we found a linker ATP, which possess a good conductive property and ends with a positive charged functional group. By using ATP, we enhanced the measured signal and improved the sensor sensitivity. Therefore, we can use a simplified electronic circuit to make the biomolecule detection. This study is useful for the point-of-care testing implementation of impedance based biosensor.
Subjects
Impedance based biosensor
Steric hindrance
Electrostatic force
Conductive linker
Point-of-care
Type
thesis
File(s)
Loading...
Thumbnail Image
Name

ntu-100-R98543008-1.pdf

Size

23.54 KB

Format

Adobe PDF

Checksum

(MD5):ba9fdb6385fb51a90ddf72eebceab125

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science