|Title:||以造膜理論控制左旋聚乳酸薄膜之裂解速度(1/2)||Authors:||楊台鴻||Keywords:||PLLA;Particulate membranes;MG-63 cells||Issue Date:||31-Jul-2004||Publisher:||臺北市：國立臺灣大學醫學工程學研究所||Abstract:||
In this work, poly l-lactide (PLLA) membranes with different morphologies were prepared and the equilibrium phase diagram of
membrane formation system of ethanol, methylene chloride, and PLLA was studied. Based on the phase diagram, particulate and
porous membranes, dominated by crystallization and liquid–liquid demixing, respectively, could be prepared by changing the PLLA
concentration of casting solution. In addition, in vitro interaction of MG-63 osteosarcoma cells and PLLA membranes with dense,
porous and particulate morphologies was investigated. It was found that the particulate membrane not only could improve cell
adhesion and growth, but also could upregulate the osteoblastic phenotype. Therefore, the PLLA membrane with particulate
morphology satisfies the biomaterial requirement necessary for temporary scaffold to transplanted osteoblasts and provides a means
for the architectural design of more complex tissue-engineered systems.
|Appears in Collections:||醫學工程學研究所|
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