https://scholars.lib.ntu.edu.tw/handle/123456789/83344
Title: | 胃液對用於藥物控制釋放高分子薄膜的影響 | Authors: | 謝銘鈞 | Keywords: | 胃液;高分子薄膜;藥物釋放;Gastric juice;polymer membrane;drug delivery | Issue Date: | 31-Jul-2001 | Publisher: | 臺北市:國立臺灣大學醫學工程學研究所 | Abstract: | 本計畫目的在於開發高分子薄膜應用 於大腸給藥的藥物控制釋放,製備能隨環 境酸鹼值改變孔洞結構的薄膜,希望藉著 改質乙烯醇共聚合物薄膜,使其帶有羧酸 基(-COOH group),在酸性環境中不帶 電;而到了微鹼性的環境則解離帶負電, 並因靜電斥力而使薄膜擴張、孔洞放大, 以助於藥物的釋放,此外並探討胃液對高 分子薄膜的影響,縮短體外實驗與體內實 驗之差距。實驗結果發現不管是乙烯醇共 聚合物薄膜或是改質後的乙烯醇共聚合物 薄膜,用於包蓋5-FU 的藥物釋放量在pH 7.4 都比pH 2.0 時要大,而在胃液的存在 下,會抑制藥物釋放量。 In this project, pH-sensitive membranes for colon-specific drug delivery will be synthesized by the covalent bonding of glycine on poly(ethylene-co-vinyl alcohol) (EVAL) membrane via isocyanation of surface hydroxyl groups of EVAL membrane and subsequent conversion to activated ester. The membranes are functioning as protective carriers of drugs in the stomach and small intestine. Regardless of the EVAL membrane and the glycine-immobilized EVAL membrane, the 5-FU permeation at pH 2.0 was small, which indicates that drugs are protected in the acidic environment. The permeability of 5-FU with gastric juice was the smallest. Gastric acid and gastrointestinal motility present a major impediment to the development of oral colon-specific delivery medication. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/29527 | Other Identifiers: | 892314B002325M08 | Rights: | 國立臺灣大學醫學工程學研究所 |
Appears in Collections: | 醫學工程學研究所 |
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892314B002325M08.pdf | 653.73 kB | Adobe PDF | View/Open |
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