https://scholars.lib.ntu.edu.tw/handle/123456789/83666
Title: | Tissue engineering-based cartilage repair with allogenous chondrocytes and gelatin–chondroitin–hyaluronan tri-copolymer scaffold: A porcine model assessed at 18, 24, and 36 weeks | Authors: | Chang, Chih-Hung Kuo, Tzong-Fu Lin, Chien-Cheng Chou, Cheng-Hung Chen, Kuang-Ho Lin, Feng-Huei Liu, Hwa-Chang |
Keywords: | Animal model; Cartilage tissue engineering; Chondroitin sulfate; Gelatin; Hyaluronan | Issue Date: | 2006 | Journal Volume: | 27 | Journal Issue: | 9 | Start page/Pages: | 1876-1888 | Source: | Biomaterials | Abstract: | We previously showed that cartilage tissue can be engineered in vitro with porcine chondrocytes and gelatin/chondoitin-6-sulfate/hyaluronan tri-copolymer which mimic natural cartilage matrix for use as a scaffold. In this animal study, 15 miniature pigs were used in a randomized control study to compare tissue engineering with allogenous chondrocytes, autogenous osteochondral (OC) transplantation, and spontaneous repair for OC articular defects. In another study, 6 pigs were used as external controls in which full thickness (FT) and OC defects were either allowed to heal spontaneously or were filled with scaffold alone. After exclusion of cases with infection and secondary arthritis, the best results were obtained with autogenous OC transplantation, except that integration into host cartilage was poor. The results for the tissue engineering-treated group were satisfactory, the repair tissue being hyaline cartilage and/or fibrocartilage. Spontaneous healing and filling with scaffold alone did not result in good repair. With OC defects, the subchondral bone plate was not restored by cartilage tissue engineering. These results show that tri-copolymer can be used in in vivo cartilage tissue engineering for the treatment of FT articular defects. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/128023 http://ntur.lib.ntu.edu.tw/bitstream/246246/128023/1/62.pdf https://www.scopus.com/inward/record.uri?eid=2-s2.0-28744449647&doi=10.1016%2fj.biomaterials.2005.10.014&partnerID=40&md5=d557194553bdc05ba2cab5cad85710a0 |
ISSN: | 01429612 | DOI: | 10.1016/j.biomaterials.2005.10.014 | SDG/Keyword: | Copolymers; Tissue; Transplants; Animal model; Cartilage tissue engineering; Gelatin; Hyaluronan; Cartilage; chondroitin; chondroitin sulfate; copolymer; gelatin; hyalin; hyaluronic acid; animal cell; animal experiment; animal model; animal tissue; arthritis; arthropathy; article; autograft; bone plate; bone remodeling; cartilage cell; cell transplantation; controlled study; experimental model; female; instrumentation; male; nonhuman; osteocyte; priority journal; randomization; satisfaction; swine; thickness; time series analysis; tissue engineering; tissue repair; Animals; Cartilage, Articular; Chondrocytes; Chondroitin; Female; Hyaluronic Acid; Knee Joint; Male; Osteochondritis; Regeneration; Sus scrofa; Tissue Engineering; Transplantation, Homologous; Animalia; Suidae; Sus scrofa |
Appears in Collections: | 醫學工程學研究所 |
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