https://scholars.lib.ntu.edu.tw/handle/123456789/83941
標題: | A laser micromachined probe for recording multiple field potentials in the thalamus | 作者: | Chen, You-Yin Kuo, Te-Son Jaw, Fu-Shan |
關鍵字: | Cross-correlation; Field potential; Laser micromachining; Multielectrode probe; Thalamus | 公開日期: | 2004 | 卷: | 139 | 期: | 1 | 起(迄)頁: | 99-109 | 來源出版物: | Journal of Neuroscience Methods | 摘要: | Multichannel recording provides integral information about electrical brain activities at one instant in time. In this study, multielectrode probes were fabricated to record the thalamic field potentials (FPs) responding to the electrical stimulation of nerve at the rat tail. At first, the number of sweeps used to form the evoked FP average and the spatial sampling density were determined by using cross-correlation functions, which were then statistically analyzed. The difference was significant at P < 0.05, if the number of sweeps for averaging was more than 50 and the spatial interval between two consecutive recording sites was less than 50 mum in the anteroposterior, mediolateral and ventrodorsal directions. The responsive area was distributed vertically in the thalamus (ventral posterior lateral (VPL) nucleus); therefore, the recording sites were arranged in one linear array. Sixteen recording sites , which were 50 mum apart from each other, were distributed in the ventrodorsal direction. A 16-channel silicon probe was fabricated by using a standard photolithography process and laser micromachining techniques. The probe provides capabilities to record multiple thalamic evoked FPs and multiunit activities simultaneously. (C) 2004 Elsevier B.V. All rights reserved. Multichannel recording provides integral information about electrical brain activities at one instant in time. In this study, multielectrode probes were fabricated to record the thalamic field potentials (FPs) responding to the electrical stimulation of nerve at the rat tail. At first, the number of sweeps used to form the evoked FP average and the spatial sampling density were determined by using cross-correlation functions, which were then statistically analyzed. The difference was significant at P<0.05, if the number of sweeps for averaging was more than 50 and the spatial interval between two consecutive recording sites was less than 50 μm in the anteroposterior, mediolateral and ventrodorsal directions. The responsive area was distributed vertically in the thalamus (ventral posterior lateral (VPL) nucleus); therefore, the recording sites were arranged in one linear array. Sixteen recording sites, which were 50 μm apart from each other, were distributed in the ventrodorsal direction. A 16-channel silicon probe was fabricated by using a standard photolithography process and laser micromachining techniques. The probe provides capabilities to record multiple thalamic evoked FPs and multiunit activities simultaneously. © 2004 Elsevier B.V. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/132501 https://www.scopus.com/inward/record.uri?eid=2-s2.0-4444365312&doi=10.1016%2fj.jneumeth.2004.04.022&partnerID=40&md5=794fcd17a8accfd5281209ab5dffdf92 |
ISSN: | 01650270 | DOI: | 10.1016/j.jneumeth.2004.04.022 | SDG/關鍵字: | silicon; analytic method; animal experiment; article; brain depth stimulation; controlled study; electric potential; electrode; evoked response; laser; male; mechanical probe; nonhuman; photolithography; priority journal; rat; recording; thalamus; thalamus ventral nucleus; Animals; Evoked Potentials; Lasers; Male; Microelectrodes; Micromanipulation; Rats; Rats, Wistar; Thalamus |
顯示於: | 醫學工程學研究所 |
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