https://scholars.lib.ntu.edu.tw/handle/123456789/84212
標題: | Fabrication, Characterization, and Application of Greigite Nanoparticles for Cancer Hyperthermia | 作者: | Chang, Yo-Sheng Savitha, S. Sadhasivam, S. Hsu, Chung-King Lin, Feng-Huei |
關鍵字: | Greigite;Magnetic property;Hyperthermia;Coprecipitation;Cancer | 公開日期: | 2011 | 起(迄)頁: | 314-319 | 來源出版物: | Journal of Colloid and Interface Science | 摘要: | Greigite is a Fe-S-containing complex having magnetic properties mainly synthesized in the solution. In the present study, greigite was synthesized by a coprecipitation method at different pH's and reaction times. The greigite phase was analyzed by the X-ray diffraction (XRD) method at an optimum pH of 3.0 and reaction time of 10 min, respectively. The magnetization characterization by superconducting quantum interference device (SQUID) revealed that the magnetic saturation was obtained at 16. 1538 (emu/g ). The inductive heating property of the greigite nanoparticles was carried out by induction heater power cube (IHPC) in an alternating current magnetic field and the results indicated that the heating effect was significant. Transmission electron microscopy (TEM) revealed that the size of the greigite was around 50-100 nm and the edges of nanoparticles have no clear boundary or distinctive morphology. Studies on LDH and WST-I assay revealed low cytotoxicity at greigite concentrations of 1 mg/ml. In vitro experiments suggested that cancerous cells, human lung adenocarcinoma epithelial cell line (A549), had the ability to become more damaged under AC magnetic field than the normal human lung cells (HFL-1). |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/242000 | DOI: | 10.1016/j.jcis.2010.06.069 | SDG/關鍵字: | AC magnetic fields; Alternating current; Cancer; Cancerous cells; Coprecipitation method; Epithelial cells; Greigites; Heating effect; Human lung; Human lung cells; Hyperthermia; In-vitro; Induction heater; Inductive heating; Optimum pH; Superconducting quantum interference device; Biological organs; Cell culture; Coprecipitation; Diseases; Electromagnetic field effects; Face recognition; Heating; Human reaction time; Induction heating; Magnetic fields; Magnetic properties; Nanoparticles; Quantum interference devices; Saturation magnetization; SQUIDs; Transmission electron microscopy; X ray diffraction; Nanomagnetics; greigite nanoparticle; iron; lactate dehydrogenase; nanoparticle; unclassified drug; adenocarcinoma; animal cell; article; assay; cancer cell; chemical reaction; controlled study; cytotoxicity; epithelioid cell; epithelium cell; heating; human; human cell; hyperthermia; in vitro study; lung adenocarcinoma; lung alveolus cell; magnetic field; morphology; mouse; nanofabrication; neoplasm; nonhuman; pH; precipitation; priority journal; quantum mechanics; transmission electron microscopy; X ray diffraction; Adenocarcinoma; Antineoplastic Agents; Cell Proliferation; Chemistry Techniques, Synthetic; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Hydrogen-Ion Concentration; Hyperthermia, Induced; Iron; Lung Neoplasms; Magnetic Fields; Nanoparticles; Particle Size; Structure-Activity Relationship; Sulfides; Surface Properties; Time Factors; Tumor Cells, Cultured |
顯示於: | 醫學工程學研究所 |
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