https://scholars.lib.ntu.edu.tw/handle/123456789/84219
標題: | Immunomagnetic Reduction for Fetal Fibronectin Detection - a Novel Method to Detect the Preterm Biomarker | 作者: | CHEN, CHEN-YU CHANG, CHIA-CHEN Yu, Chun YANG, SHIEH-YUEH LIN, CHII-WANN |
關鍵字: | Preterm birth;Fetal fibronectin;Immunomagnetic reduction | 公開日期: | 2011 | 卷: | v.23 | 期: | n.4 | 起(迄)頁: | 27-3 | 來源出版物: | Biomedical Engineering: Applications, Basis and Communications | 摘要: | Preterm birth is the main cause of perinatal morbidity and mortality throughout the world. Fetal fibronectin (fFN) is one type of glycoprotein detected in the interface of the choriodecidual junction. Preterm labor is related to the disruption of the choriodecidual junction and thus fFN releases in the ectocervix or posterior vaginal fornix. Quantization of fFN can assist the diagnosis and prevention of preterm birth. In this work , we developed an immunoassay, the immunomagnetic reduction (IMR), to quantitatively detect fFN. It was found that the low detection limit for fFN via IMR is less than 10 ng/ml, which is much lower than clinic criteria 50 ng/ml. In addition to the high sensitivity, IMR assay shows such merits as low cost and high reliability for detecting fFN. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/242016 | DOI: | 10.4015/S1016237211002621 |
顯示於: | 醫學工程學研究所 |
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