https://scholars.lib.ntu.edu.tw/handle/123456789/84223
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 醫工所 | en |
dc.contributor.author | PENG, CHENG-LIANG | en |
dc.contributor.author | TSAI, HAN-MIN | en |
dc.contributor.author | YANG, SHU- JYUAN | en |
dc.contributor.author | LUO, TSAI-YUEH | en |
dc.contributor.author | LIN, WUU-JYH | en |
dc.contributor.author | SHIEH, MING- JIUM | en |
dc.contributor.author | SHIEH, MING-JIUM | en |
dc.creator | 彭正良;蔡翰旻;楊淑娟;羅彩月;林武智;謝銘鈞 | zh-tw |
dc.creator | PENG, CHENG-LIANG;TSAI, HAN-MIN;YANG, SHU- JYUAN;LUO, TSAI-YUEH;LIN, WUU-JYH;SHIEH, MING- JIUM;SHIEH, MING-JIUM | en |
dc.date | 2011 | en |
dc.date.accessioned | 2012-07-13T01:53:00Z | - |
dc.date.accessioned | 2018-06-29T01:31:35Z | - |
dc.date.available | 2012-07-13T01:53:00Z | - |
dc.date.available | 2018-06-29T01:31:35Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/242024 | - |
dc.description.abstract | Thermosensitive nanoparticles based on polyN- isopropylacrylamide-co-2- dimethylaminoethylmethacrylate polyNIPA-co-DMAEMA copolymers were successfully fabricated by free radical polymerization. The lower critical solution temperature LCST of the synthesized nanoparticles was 41 degrees C and a temperature above which would cause the nanoparticles to undergo a volume phase transition from 140 to 100 nm, which could result in the expulsion of encapsulated drugs. Therefore, we used the polyNIPA-co- DMAEMA nanoparticles as a carrier for the controlled release of a hydrophobic anticancer agent, 7-ethyl-10-hydroxy- camptothecin SN-38. The encapsulation efficiency and loading content of SN-38-loaded nanoparticles at an SN-38/polyNIPA- co-DMAEMA ratio of 1/10 D/P = 1/10 were about 80% and 6.293% , respectively. Moreover, the release profile of SN-38- loaded nanoparticles revealed that the release rate at 42 degrees C above LCST was higher than that at 37 degrees C below LCST, which demonstrated that the release of SN-38 could be controlled by increasing the temperature. The cytotoxicity of the SN-38-loaded polyNIPA-co-DMAEMA nanoparticles was investigated in human colon cancer cells HT-29 to compare with the treatment of an anticancer drug, Irinotecan R CPT-11. The antitumor efficacy evaluated in a C 26 murine colon tumor model showed that the SN- 38-loaded nanoparticles in combination with hyperthermia therapy efficiently suppressed tumor growth. The results indicate that these thermo-responsive nanoparticles are potential carriers for controlled drug delivery. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | NANOTECHNOLOGY v.22 n.26 pp.AR 265608 | en |
dc.relation.ispartof | NANOTECHNOLOGY | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Development of Thermosensitive Polyn-Isopropylacrylamide-Co-2- Dimethylamino Ethyl Methacrylate-Based Nanoparticles for Controlled Drug Release | en |
dc.relation.pages | - | - |
dc.relation.journalvolume | v.22 | - |
dc.relation.journalissue | 265608 | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學工程學研究所 |
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