https://scholars.lib.ntu.edu.tw/handle/123456789/87049
標題: | Heavy incense burning in temples promotes exposure risk from airborne PMs and carcinogenic PAHs | 作者: | Chiang, Kuo-Chih Liao, Chung-Min |
關鍵字: | HRT model; Incense burning; Particulate matters; PBPK model; Polycyclic aromatic hydrocarbons; Risk assessment; Temple | 公開日期: | 2006 | 卷: | 372 | 期: | 1 | 起(迄)頁: | 64-75 | 來源出版物: | Science of The Total Environment | 摘要: | We present the mechanistic-based exposure and risk models, appraised with reported empirical data, to assess how the human exposure to airborne particulate matters (PMs) and carcinogenic polycyclic aromatic hydrocarbons (PAHs) during heavy incense burning episodes in temples. The models integrate size-dependent PM levels inside a temple from a published exploratory study associated with a human expiratory tract (HRT) model taking into account the personal exposure levels and size distributions in the HRT. The probabilistic exposure profiles of total-PAH levels inside a temple and internal PAHs doses are characterized by a physiologically based pharmacokinetic (PBPK) model with the reconstructed dose-response relationships based on an empirical three-parameter Hill equation model, describing PAHs toxicity for DNA adducts formation and lung tumor incidence responses in human white blood cells and lung. Results show that the alveolar-interstitial (AI) region has a lower mass median diameter (0.29?μm) than that in extrathoracic (ET1, 0.37?μm), brochial (BB, 0.36?μm) and bronchiolar (bb, 0.32?μm) regions. The 50% probability (risk = 0.5) of exceeding the DNA adducts frequency (DAf) ratio of 1.28 (95% CI: 0.55-2.40) and 1.78 (95% CI: 0.84-2.95) for external exposure of B[a]P and B[a]Peq, respectively. The 10% (risk = 0.1) probability or more of human affected by lung tumor is approximately 7.62 × 10- 5% (95% CI: 3.39 × 10- 5-1.71 × 10- 4%) and 3.87 × 10- 4% (95% CI: 1.72 × 10- 4-8.69 × 10- 4%) for internal exposure of B[a]P and B[a]Peq, respectively. Our results implicate that exposure to smoke emitted from heavy incense burning may promote lung cancer risk. Our study provides a quantitative basis for objective risk prediction of heavy incense burning exposure in temples and for evaluating the effectiveness of management. ? 2006 Elsevier B.V. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/176022 | DOI: | 10.1016/j.scitotenv.2006.08.012 | SDG/關鍵字: | Particles (particulate matter); Pharmacokinetics; Physiological models; Polycyclic aromatic hydrocarbons; Risk assessment; Tumors; HRT model; Incense burning; PBPK model; Temples; Health risks; benzo[a]pyrene; polycyclic aromatic hydrocarbon; burning; health risk; PAH; particulate matter; airborne particle; article; cancer incidence; cancer risk; carcinogenic activity; confidence interval; DNA adduct; dose response; environmental exposure; Hill reaction; leukocyte; lung cancer; lung interstitium; lung tumor; particle size; particulate matter; priority journal; risk assessment; Air Pollutants; Air Pollution, Indoor; Carcinogens, Environmental; Humans; Inhalation Exposure; Lung Neoplasms; Models, Biological; Particle Size; Particulate Matter; Polycyclic Hydrocarbons, Aromatic; Religion; Respiratory System; Risk Assessment; Taiwan |
顯示於: | 生物環境系統工程學系 |
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