https://scholars.lib.ntu.edu.tw/handle/123456789/87051
Title: | Modelling vaccination programmes against measles in Taiwan | Authors: | CHEN, S. C. CHANG, C. F. JOU, L. J. CHUNG-MIN LIAO |
Issue Date: | 2006 | Journal Volume: | 135 | Journal Issue: | 5 | Start page/Pages: | 775-786 | Source: | Epidemiology and Infection | Abstract: | Vaccination has proved a powerful defence against measles. We reappraise measles seroepidemiological data in Taiwan from 1974 to 2004 having robust age-stratified serological information on exposure and immunity to quantitatively characterize measles vaccination programmes. We dynamically model measles seroepidemiology to estimate age-dependent intensity of infection associated with the effects of different contact patterns on pre- and post-vaccination. The WAIFM (who acquires infection from whom) contact matrix is employed to describe the transmission between and within each age group. A deterministic SEIR (susceptible-exposed-infected-recovery) model is used to capture subpopulation dynamics. Our study shows that mass regional or nationwide vaccination programmes could greatly reduce the potential for a major measles epidemic and have strong direct effects on the potential impact of childhood vaccination. We parameterize a predictive model that should reduce the socio-economic costs of measles surveillance in Taiwan and thereby encourage its continuance, especially for preschool children ? 2006 Cambridge University Press. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/176024 | DOI: | 10.1017/S0950268806007369 | SDG/Keyword: | measles vaccine; adolescent; adult; article; child; controlled study; cost control; data analysis; epidemic; epidemiological data; health program; human; infant; infection control; infection risk; mathematical model; measles; Measles virus; outcome assessment; prediction; preventive health service; risk assessment; seroprevalence; socioeconomics; Taiwan; virus transmission; Adolescent; Adult; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Measles; Measles Vaccine; Models, Biological; Taiwan; Vaccination |
Appears in Collections: | 生物環境系統工程學系 |
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