https://scholars.lib.ntu.edu.tw/handle/123456789/87837
標題: | 長鏈多不飽和脂肪酸對轉錄因子 ADD1和脂肪酸合成之影響機制 | 作者: | 丁詩同 | 關鍵字: | 脂肪細胞分化決定因子1;脂肪酸合成;多不飽和脂肪酸;ADD1;FAS;PUFA | 公開日期: | 2002 | 出版社: | 臺北市:國立臺灣大學動物科學技術學系暨研究所 | 摘要: | 飼糧添加脂肪除提供能量等基本功能 外,脂肪酸的變化更可以改變組織中脂肪酸 的組成,調節各組織的生理代謝。在豬方面, 其脂肪之生合成與堆積,主要發生在脂肪組 織,並且調控此相關代謝之轉錄因子-脂肪細 胞分化決定因子一(ADD1) 也主要表達於 此。許多試驗指出,多不飽和脂肪酸(PUFA) 可藉由抑制ADD1 之表現,減少脂肪細胞堆 積脂肪。本研究試驗中發現,二十二碳六烯 酸(DHA)抑制ADD1 表現,而抗氧化劑的添 加(400 nM N,N’-diphenyl-1,4-diphenylenediamine, 15 M (+)--tocopherol acid succinate, 600 nM butylated hydroxytoluene, and 160 nM deferoxamine mesylate)可 以彌補此抑制效果,顯示DHA 對ADD1 表 現的調節與脂肪酸的氧化作用有關。而在抗 氧化基因與類前列腺素的試驗中,我們無法 進一步證明多不飽和脂肪酸抑制ADD1 之表 現只經由脂肪酸的過氧化機制。簡言之,我 們可知PUFA 抑制ADD1 mRNA 的表現,以 達到抑制脂肪細胞內脂肪之堆積,惟其所產 生之類前列腺素代謝產物對ADD1 影響機制 待尚進一步之試驗證明。 Supplementation of dietary fat provides energy for animals. Fatty acid composition in many tissues of animals can be modified by dietary fat sources that have different fatty acid (FA) composition. Such a modification may regulate some physiological functions. In pigs, the FA de novo synthesis and fat accumulation is primarily located in adipose tissues. The adipocyte determination and differentiation factor 1(ADD1) expressed highly in adipose tissue. It has been shown that polyunsaturated fatty acid (PUFA) reduced fat deposition in adipocyte by inhibiting ADD1 expression. Current research showed that docosahexaenoic acid (DHA) inhibited ADD1 expression. The inhibition could be recovered by adding antioxidant mixture ( 400 nM N,N’-diphenyl- 1,4-diphenylenediamine, 15 M (+)--tocopherol acid succinate, 600 nM butylated hydroxytoluene, and 160 nM deferoxamine mesylate ) , indicating the inhibitory effect of DHA to the expression of ADD1 was partially due to PUFA peroxidation, however. We could not further prove whether the inhibition of ADD1 expression by PUFA is solely via fatty acids peroxidation mechanism. In conclusion, PUFA inhibit fat deposition in adipocyte by reducing ADD1 mRNA expression, but the detail mechanism remains to be determined. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/16448 | 其他識別: | 902313B002304 | Rights: | 國立臺灣大學動物科學技術學系暨研究所 |
顯示於: | 動物科學技術學系 |
檔案 | 描述 | 大小 | 格式 | |
---|---|---|---|---|
902313B002304.pdf | 383.92 kB | Adobe PDF | 檢視/開啟 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。