Immunomodulatory Properties of Multi-ingredient Health Food Formula
Date Issued
2008
Date
2008
Author(s)
Tsai, Ming-Jer
Abstract
Abstract The objective of this study was to evaluate the immunomodulatory effects of multi-ingredients health food formulas A, B, C, I, K and J. Results of the evaluation on non-specific immunomodulatory properties demonstrated that the administration of formula A at low dose (15.5 mg/mouse), formula C at high and low doses (15.5 and 3.1 mg/mouse, respectively), formula I at high and low doses (18.9 and 1.1 mg/mouse, respectively) and formula J at high and medium doses significantly (p<0.05) enhanced cell proliferation of mouse splenocytes. Administration of formula A at high and low doses (15.5 and 3.1 mg/mouse, respectively), formula C at high dose, formula I at high and low doses and formula J at high, medium and low doses (27.8 mg/mouse, 9.3 mg/mouse, 3.1 mg/mouse) significantly (p<0.05) increased IFN-γ secretion by mouse splenocytes. Administration of formula I at high dose significantly (p<0.05) increased IL-2 secretion by mouse splenocytes. Administration of formula A at high and low doses, formula I at high dose and formula J at high and medium doses significantly (p<0.05) enhanced the NK cell activity of mouse splenocytes. Administration of formula A at high does, formula C at low dose, formula I at low dose as well as formula J at high and medium doses significantly (p<0.05) enhanced the phagocytosis activity of monocytes. Administration of formula A at high dose, formula C at high and low doses, formula I at high and low doses and formula J at high, medium and low doses significantly (p<0.05) increased IFN-γ secretion in mouse sera. Administration of formula I at high and low doses and formula J at high dose significantly (p<0.05) increased IL-2 secretion in mouse sera. Administration of formula A at high dose, formula I at high and low doses and formula J at high, medium and low doses significantly (p<0.05) increased total IgG secretion in mouse sera. Results of the evaluation of OVA-specific immunomodulatory properties showed that administration of formula A at high and low doses, formula C at high dose, formula I at high and low doses and formula J at high, medium and low doses significantly (p<0.05) enhanced OVA-specific cell proliferation of mouse splenocytes. Administration of formula C at high dose, formula I at high dose and formula J at high and medium doses significantly (p<0.05) increased OVA-specific IFN-γ secretion by mouse splenocytes. Administration of formula C at high and low doses, and formula J at high dose significantly (p<0.05) increased OVA-specific IL-2 secretion by mouse splenocytes. Administration of formula A at high and low doses, formula C at high and low doses, formula I at high and low doses and formula J at high, medium and low doses significantly (p<0.05) enhanced OVA-specific IgG ecretion in mouse sera. These results suggested that administration of formula A, C, I and J showed both non-specific and OVA-specific immunomodulatory activities. These data of multi-ingredient health food formulas can be used as scientific vidences in health food applications.eyword : multi-ingredient health food formula, non-specific immunomodulatory activity, OVA-specific immunomodulatory activity
Subjects
multi-ingredient health food formula
non-specific immunomodulatory activity
OVA-specific immunomodulatory activity
Type
thesis
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