Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Bioresources and Agriculture / 生物資源暨農學院
  3. Food Science and Technology / 食品科技研究所
  4. Evaluation of hepatic protection of Agaricus blazei-based herbal extract against CCl4-induced oxidative liver injury
 
  • Details

Evaluation of hepatic protection of Agaricus blazei-based herbal extract against CCl4-induced oxidative liver injury

Date Issued
2007
Date
2007
Author(s)
Yen, Chih-Tai
DOI
zh-TW
URI
http://ntur.lib.ntu.edu.tw//handle/246246/56279
Abstract
Mushrooms have been used as an important source of nutrition and/or therapy throughout the world since ancient times. Agaricus blazei polysaccharides has been reported to induced with immunomodulatory and antitumor activities. This study was designed to evaluate the effects of Agaricus blazei-based herbal extract on CCl4-induced chronic hepatotoxicity in rats. Male Wistar rats (210 ±10 g) were divided into six groups in this study, including normal control (not treated with CCl4) and groups treated with CCl4, i.e. negative control (only treated with CCl4), positive control (treated with CCl4 and Silymarin), and three experimental groups (treated with CCl4 and low, medium or high dose of Agaricus blazei-based herbal extract, i.e. 0.74, 1.48, or 3.7g/kg bw/day Agaricus blazei-based herbal extract, respectively). On the other hand, rats were administrated with Agaricus blazei-based herbal extract for one week before the administration of CCl4. Rats were treated with Agaricus blazei-based herbal extract once a day until the eighth week of CCl4 treatment. Blood samples were collected for assaying serum biological parameters. The livers were excised for evaluating peroxidation products and antioxidant substances, as well as the activities of antioxidant enzymes. Pathological histology was also performed. The results showed that the Agaricus blazei-based herbal extract significantly (p<0.05) lowered the serum levels of hepatic enzyme markers (alanine aminotransferase, aspartate aminotransferase), inhibited inflammation, necrosis, fatty degeneration and fibrosis. Also reduced the content of the peroxidation product malondialdehyde, and the elevated the content of reduced form of glutathione (GSH). Treatment of rats with Agaricus blazei-based herbal extract could increase the activities of glutathione peroxidase (GPx1), glutathione reductase (GRd) and glutathione S-transferase (GST) in liver when compared with CCl4-treated group (p<0.05). Therefore, the results of this study show that Agaricus blazei-based herbal extract can be proposed to protect the liver against CCl4-induced oxidative damage in rats, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenger effects.
Subjects
肝臟
巴西洋菇
四氯化碳
麩胱甘肽
抗氧化
解毒代謝
liver
Agaricus blazei
carbon tetrachloride
glutathione
antioxidant property
detoxification
Type
thesis
File(s)
Loading...
Thumbnail Image
Name

ntu-96-R94641025-1.pdf

Size

23.53 KB

Format

Adobe PDF

Checksum

(MD5):1dfca7a6c291602aac71d654623d364b

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science