https://scholars.lib.ntu.edu.tw/handle/123456789/96803
DC 欄位 | 值 | 語言 |
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dc.contributor | 張鴻民 | en |
dc.contributor | 臺灣大學:食品科技研究所 | zh_TW |
dc.contributor.author | 張佳惠 | zh |
dc.contributor.author | Chang, Jia-Huei | en |
dc.creator | 張佳惠 | zh |
dc.creator | Chang, Jia-Huei | en |
dc.date | 2005 | en |
dc.date.accessioned | 2007-11-27T03:19:10Z | - |
dc.date.accessioned | 2018-06-29T07:29:24Z | - |
dc.date.available | 2007-11-27T03:19:10Z | - |
dc.date.available | 2018-06-29T07:29:24Z | - |
dc.date.issued | 2005 | - |
dc.identifier | zh-TW | en |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/56310 | - |
dc.description.abstract | 本研究以愛玉子多胜肽區分(polypeptide fraction, PF)於體外細胞模式(in vitro)下探討PF抑制白血病細胞(U937)生長並促使其分化及誘導細胞凋亡之能力,並以動物模式(in vivo)探討愛玉子PF於生物體內經由免疫調節方式達到抗CT26腫瘤的效果。將濃度為100 μg/mL之愛玉子PF刺激人類單核球細胞一天所製備之單核細胞條件培養液(mononuclear cell conditioned media, MNC-CMs),可有效抑制U937細胞生長(94%),且以NBT還原陽性率測試、NSE陽性率、型態學觀察及細胞表面抗原檢測下,皆可顯示U937細胞株可被誘導分化為正常的單核或巨噬細胞。而此單核細胞條件培養液中亦可測得高量的IL-1β(4446.5±58.5 pg/mL)、TNF-α(1324.8±90.6 pg/mL)、GM-CSF(305.9±13.2 pg/m)及IFN-γ(1557.7±16.2 pg/mL)等細胞激素。將愛玉子PF(100 μg/mL)與U937共同培養,其生長抑制率可達90%以上,且會使U937細胞週期停滯,而於DNA片段化、Annexin-V檢測可知PF可誘使細胞凋亡之發生,具有濃度及時間效應;而由流式細胞儀檢測可知,PF亦會影響粒腺體膜電位且活化caspase-3。故可得知,由PF所製備之單核細胞條件培養液可誘導白血病細胞株分化,而將PF與白血病細胞株共同培養則可誘導細胞凋亡,兩者皆可抑制白血病細胞生長。 另外為了研究愛玉子PF於生物體內經由免疫調節方式達到抗腫瘤的效果,在Balb/c小鼠皮下移植大腸癌細胞(CT26)形成腫瘤,分別於施打腫瘤同時(處理組)或待腫瘤長出後(治療組)及腫瘤移植前(預防組)餵食愛玉子PF。結果發現,處理組之小鼠餵食愛玉子PF劑量為150 mg/kg bw/day時能明顯抑制腫瘤生長(35.9%),同時能促進移植腫瘤小鼠之脾臟細胞增生及提高其脾臟細胞內TH、TC及巨噬細胞比例。而治療組當投予小鼠每公斤體重100 mg劑量之愛玉子PF可有效抑制腫瘤生長,但其促進脾臟細胞增生能力則不明顯。而預防組之結果顯示,當小鼠先給予劑量為100及200 mg/kg bw/day之愛玉子PF後,其腫瘤抑制率可高達58.1及62.8%,若配合5-FU之使用,抑制率更高達81%左右,但愛玉子PF無法改善因5-FU所引起的脾臟腫大及脾臟增生能力降低之現象。顯示愛玉子PF於細胞模式及動物模式下皆具有抑制腫瘤生長及具有免疫調節能力。 | zh_TW |
dc.description.abstract | Polypeptide fraction (PF) from jelly-fig (Ficus awkeotsang Makino) achenes was prepared to determine its effect on proliferation, differentiation, and apoptosis of human leukemic cells (U937) in vitro and immunomodulation and antitumor of CT26 in vivo. First, human peripheral blood mononuclear cells were stimulated by PF (100 μg/mL) for 1 day to prepared conditioned media (PF-MNC-CM-1). With which high growth inhibition (94%) on U937 cells and nitroblue tetrazolium (NBT) positive percentage, nonspecific esterase (NSE) positive percentage and surface antigen expressions of differentiated cells were observed. By morphological examination, U937 cells were confirmed to be differentiated into mature monocytes or/and macrophages. Through an ELISA, we found that MNC-CM-1 (stimulated by 100 μg/mL PF) contained high levels of IL-1β (4446.5±58.5 pg/mL), TNF- | en |
dc.description.tableofcontents | 摘 要……………………………………………………………….I Abstract………………………………………………………………….III 第一章 文獻整理……………………………………………………..1 第一節 愛玉子………………………………………………..1 1-1-1 愛玉子果膠酯酶抑制劑. …………………………………..2 第二節 白血病………………………………………………..3 1-2-1 白血病之定義及分類………………………………………3 1-2-2 白血病之流行病學與病理因素. …………………………..5 1-2-3 白血病之治療方法…………………………………………5 第三節 人類白血病細胞株U937及誘導分化之特性……………..6 1-3-1 U937細胞株之建立………………………………………..6 1-3-2 U937細胞株之特性………………………………………..6 1-3-3 評估U937細胞株分化之方法…………………………….8 第四節 以人類周邊血液單核球細胞(peripheral blood mononuclear cells, PBMNC)探討食品對腫瘤免疫之研究…………10 1-4-1 以PBMNC探討間接誘導U937分化之研究……………10 1-4-2 PBMNC之應用…………………………………………...11 第五節 細胞週期(cell cycle)…………………………………….11 1-5-1 細胞週期調控因子………………………………………..12 第六節 細胞凋亡作用(apoptosis)……………………………….14 1-6-1 細胞凋亡的特徵…………………………………………..14 1-6-2 細胞凋亡之調控機轉……………………………………..15 第六節 以移植腫瘤小鼠之動物模式探討食品對免疫調節抗腫瘤之研究…………………………………………………...19 1-6-1 小鼠大腸癌細胞株(CT26)之簡介…………………….19 1-6-2 氟尿嘧啶(5-Fluorouracil, 5-FU)之抗癌效果………….20 第二章 實驗架構……………………………………………………..23 第三章 愛玉子PF抑制人類白血病細胞增殖與誘導其分化及細胞凋亡作用. …………………………………………………………33 第一節 摘要…………………………………………………33 第二節 前言…………………………………………………34 第三節 實驗材料…………………………………………….35 3-3-1 愛玉來源. …………………………………………………35 3-3-2 實驗細胞……………………………………………………35 3-3-3實驗藥品及試劑…………………………………………….35 3-3-4 實驗器材…………………………………………………..39 3-3-5 儀器設備. …………………………………………………40 第四節 實驗方法…………………………………………….41 3-4-1 愛玉子多 | zh_TW |
dc.language | zh-TW | en |
dc.language.iso | en_US | - |
dc.subject | 誘導分化 | en |
dc.subject | 細胞凋亡 | en |
dc.subject | 愛玉瘦果 | en |
dc.subject | 多胜肽 | en |
dc.subject | 區分 | en |
dc.subject | 單核細胞條件培養液 | en |
dc.subject | differentiation induction | en |
dc.subject | apoptosis | en |
dc.subject | MNC-CNs | en |
dc.subject | Jelly-fig | en |
dc.subject | Polypeptide Fraction | en |
dc.title | 愛玉瘦果中多胜肽區分之抗腫瘤及免疫調節作用 | zh |
dc.title | Anti-tumor and Immunomodulation of Polypeptide Fraction from Jelly-fig (Ficus awkeotsang Makino) Achenes | en |
dc.type | thesis | en |
dc.relation.reference | 三宅捷,大野成雄。1932。愛玉子黏性物質研究第三報。熱帶農學會 誌。4(3): 295-299。 三宅捷,大野成雄。1932。愛玉子黏性物質研究第四報。熱帶農學會誌。4(3): 270-272。 王聲遠、許敏玲、李旭生、蕭明熙。1996。靈芝與雲芝免疫增強作用之研究。行政院衛生署中醫藥年報。12(3): 257-275。 李佳佩。2001。愛玉子果膠酯酶抑制劑之理化性質分析及應用性探討。國立台灣大學食品科技研究所碩士論文。 李柏宏。2000。愛玉子凝膠性質及愛玉凍品質之研究。國立台灣大學農業化學研究所博士論文。 林讚標。1991。愛玉子專論。林業叢刊第36號。台灣省林業試驗所編印。台北。 姜紹青。1993。5-Fluorouracil的過去與未來。中華民國癌症醫學會雜誌。9(2): 22-31。 徐麗嵐。2002。以柳松菇與鴻喜菇誘導人類白血病細胞 (U937) 分化及對 Balb/c 鼠皮下移植 CT26 腫瘤之抑制效果。國立台灣大學食品科技研究所碩士論文。 陳治平,邱宗傑。1998。5-Fluorouracil的代謝及其高劑量化學治療的神經毒性。當代醫學。25(7): 62-67。 黃永傳,蔡紋州,王芬芳。1967。台灣果膠資源之調查,Ⅱ、蔬菜及其他特殊植物中各部位之果膠含量。中國園藝。13: 1-11。 溫武慶,1996a。急性白血病。健康世界 130(250): 89-91。 廖慧芬。2002。黑大豆活性多醣體之分析及其經由調節免疫提升造血功能與抑制腫瘤生長之研究。國立陽明大學傳統醫藥學研究所博士論文。 歐馨婷。2001。多種蔬菜抑制人類白血病細胞(U937)增殖與誘導其分化之探討。國立台灣大學食品科技研究所碩士論文。 Anthony RS, McKelvie ND, Cunningham AJ, Craig JI, Rogers SY, Parker AC. 1998. Flow cytometry using annexin V can detect early apoptosis in peripheral blood stem cell harvests from patients with leukaemia and lymphoma. Bone Marrow Transplant 21(5): 441-446. Aranha O. Wood DP Jr, Sarkar FH. 2000. Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res 6(3): 891-900. Arends MJ, Wyllie AH. 1991. Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol 32: 223–254. Ashkenazi A, Dixit VM. 1998. Death receptors: signaling and modulation. Science 281(5381): 1305-1308. Asou H, Koshizuka K, Kyo T, Takata N, Kamada N, Koeffier HP. 2002. Resveratrol, a natural product derived from grapes, is a new inducer of differentiation in human myeloid leukemias. Int J Hematol 75(5): 528-533. Ault KA, Springer TA. 1981. Cross-reaction of a rat-anti-mouse phagocyte -specific monoclonal activity (anti-mac-1) with human monocytes NK cells. J Immunol 126(1): 359-364. Baehner RL, Nathan DG. 1968. Quantitative nitroblue tetrazolium test in chronic granulomatous disease. New Engl J Med 278(18): 971-976. Ball ED, Guyre PM, Shen L, Glynn JM, Maliszewski CR, Baker PE, Fanger MW. 1984. Gamma interferon induces monocytoid differentiation in the HL-60 cell line. J Clin Invest 73(4): 1072-1077. Barkett M, Xue D, Horvitz HR, Gilmore TD. 1997. Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro. J Biol Chem 272(47): 29419-22942. Bellamy CO, Malcomson RD, Harrison DJ, Wyllie AH. 1995. Cell death in health and disease: the biology and regulation of apoptosis. Semin Cancer Biol 6(1): 3-16. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the priciple of protein-dye binding. Anal Biochem 72: 248-254. Bratton SB, MacFarlane M, Cain K, Cohen GM. 2000. Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis. Exp Cell Res 256(1): 27-33. Brossard M, Wikel SK. 1997. Immunology of interactions between ticks and hosts. Med Vet Entomol 11(3): 270-276. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. 1999. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15: 269-290. Caballero GA, Ausma RK, Quebbema EJ. 1985. Long-term, ambulatory, continuous infusion of 5-FU for the treatment of advanced adenocarcinoma. Cancer Treat Rep 69(1): 13-16. Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B. 1975. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA 72(9): 3666-3670. Carter, SK. 1977. Clinical trials in cancer chemotherapy. Cancer 40 (1 Suppl): 544-557. Chai JG, Bando T, Kobashi S, Oka M, Nagasawa H, Nakai S, Maeda K, Himeno K, Sato M, Ohkubo S. 1992. An extract of seeds from Aeginetia indica L., a parasitic plant, induces potent antigen-specific antitumor immunity in Meth A-bearing BALB/c mice. Cancer Immunol Immunother 35(3): 181-185. Chaplin MF, Kennedy JF. 1994. Carbohydrate analysis, 2nd ed. Oxfold, New York. Chen YJ, Shiao MS, Lee SS, Wang SY. 1997. Effect of Cordyceps sinensis on the proliferation differentiation of human leukemic U937 cells. Life Sci 60(25): 2349-2359. Chen YY, Chang HM. 2004. Antiproliferative and differentiating effects of polysaccharide fraction from fu-ling (Poria cocos) on human leukemic U937 and HL-60 cells. Food Chem Toxicol 42(5): 759-769. Cohen GM. 1997. Caspases: the executioners of apoptosis. Biochem J 326(Pt 1): 1-16. Cosulich SC, Savory PJ, Clarke PR. 1999. Bcl-2 regulates amplification of caspase activation by cytochrome c. Curr Biol 9(3): 147-150. Dalton WTT, Ahearn MJ, McCredie KB, Freireich EJ, Stass SA, Trujillo JM. 1988. HL-60 cell line was derived from a patient with FAB-M2 not FAB-M3. Blood 71(1): 242-247. De Falco M, Fedele V, Cobellis L, Mastrogiacomo A, Leone S, Giraldi D, De Luca B, Laforgia V, De Luca A. 2004. Immunohistochemical distribution of proteins belonging to the receptor-mediated and the mitochondrial apoptotic pathways in human placenta during gestation. Cell Tissue Res 318(3): 599-608. Derradji H, Baatout S. 2003. Apoptosis: a mechanism of cell suicide. In Vivo 17(2): 185-192. Dexter TM, Heyworth CM. 1994. Growth factors and the molecular control of haematopoiesis. Eur J Clin Microbiol Infect Dis 13(2): S3-S8. Dinarello CA. 1991. Interleukin-1 and interleukin-1 antagonism. Blood 77(8): 1627-1752. Du C, Fang M, Li Y, Li L, Wang X. 2000. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102(1): 33-42. Dyson N. 1998. The regulation of E2F by pRB-family proteins. Genes Dev 12(15): 2245-2262. Earnshaw WC, Martins LM, Kaufmann SH. 1999. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68:383-424. Emaus RK, Grunwald R, Lemasters JJ. 1986. Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochim Biophys Acta 850(3): 436-448. Emmenegger U, Man S, Shaked Y, Francia G, Wong JW, Hicklin DJ, Kerbel RS. 2004. A comparative analysis of low-dose metronomic cyclophosphamide reveals absent or low-grade toxicity on tissues highly sensitive to the toxic effects of maximum tolerated dose regimens. Cancer Res 64(11): 3994-4000. Evan GI, Vousden KH. 2001. Proliferation, cell cycle and apoptosis in cancer. Nature 411(6835): 342-348. Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM. 1992. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 148(7): 2207-2216. Fesik SW, Shi Y. 2001. Structural biology. Controlling the caspases. Science 294(5546): 1477-1478. Foon KA. 1989. Biological response modifiers: The new immunotherapy. Cancer Res 49(7): 1621-1639. Frederich M, Bentires-Alj M, Tits M, Angenot L, Greimers R, Gielen J, Bours V, Merville MP. 2003. Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, induces cell cycle arrest and apoptosis in human colon cancer cells. J Pharmacol Exp Ther 304(3): 1103-1110. Gallagher R, Collin S, Trujillo J, McCredie K, Ahearn M, Tsai S, Metzgar G, Aulakh G, Ting R, Ruscetti F, Gallo R. 1979. Characterization of the continuous differentiating cell line (HL-60) from a patient with acute promyelocytic leukemia. Blood 54(3): 713-733. Gasson JC. 1991. Molecular physiology of granulocyte-macrophage colony-stimulating factor. Blood 77(6): 1131-1145. Goldstein S, Korczack LB. 1981. Status of mitochondria in living human fibroblasts during growth and senescence in vitro: use of the laser dye rhodamine 123. J Cell Biol 91(2): 392-398. Golgher D, Korangy F, Gao B, Gorski K, Jaffee E, Edidin M, Pardoll DM, Elliott T. 2001. An immunodominant MHC class II-restricted tumor antigen is conformation dependent and binds to the endoplasmic reticulum chaperone, calreticulin. J Immun 167(1): 147-155. Goliaei B, Deizadji A. 1998. Effects of hyperthermia granulocyte-marcophage colony-stimulating factor on the differentiation of human leukemic cell line U937. Leuk Res 22(8): 705-710. Goyert SM, Ferreo EM, Seremetis SV, Winchester RJ, Silver J, Mattison AC. 1986. Biochemistry expression of myelomonocytic antigens. J Immunol 137(12): 3909-3914. Green DR, Reed JC. 1998. Mitochondria and apoptosis. Science 281(5381): 1309-1312. Greenberg PD. 1991. Adoptive T cell therapy of tumors: mechanisms operative in the recognition and elimination of tumor cells. Adv Immunol 49: 281-355. Greene WC, Parker CM, Parker CW. 1976. Opposing effects of mitogenic and nonmitogenic lectins on lymphocyte activation. Evidence that wheat germ agglutinin produces a negative signal. J Biol Chem 251(13): 4017-4025. Grinius LL, Jasaitis AA, Kadziauskas YP, Liberman EA, Skulachev VP, Topali VP, Tsofina LM, Vladimirova MA. 1970. Conversion of biomembrane-produced energy into electric form. I. Submitochondrial particles. Biochim Biophys Acta 216(1): 1-12. Haanen C, Vermes I. 1996. Apoptosis: programmed cell death in fetal development. Eur J Obstet Gynecol Reprod Biol 64(1): 129-133. Harrison. 1995. Harrison’s priciples of internal medicine, 14th ed. McGraw-Hill, Health Professions Division, New York. Hatake K, Motoyoshi K, Hunamura N, Mukaida N, Kasahara T, Miura Y, Saito M. 1987. Differentiation-inducing factor for a human leukemic cell line produced by colony-stimulating factor producing human lung cancer tissue. Exp Hematol 15(9): 915-921. Hegde R, Srinivasula SM, Zhang Z, Wassell R, Mukattash R, Cilenti L, DuBois G, Lazebnik Y, Zervos AS, Fernandes-Alnemri T, Alnemri ES. 2002. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J Biol Chem 277(1): 432-438. Heidelberg C, Ansfield FJ. 1963. Experimental and clinical use of fluorinated pyrimidines in cancer chemotherapy. Cancer Res 23(5): 1226-1243. Heimdal JH, Aarstad HJ, Aakvaag A, Olofsson J. 1997. In vitro T-lymphocyte fnction in head and neck cancer patients. Eur Arch Otorhinolaryngol 254(7): 318-322. Hemmi H, Nakamura T, Shimizu Y, Sugamura K. 1989. Identification of components of differentiation-inducing activity of human T-cell lymphoma cells by induction of differentiation in human myeloid leukemia cells. J Natl Cancer Inst 81(12): 952-956. Ho A, Dowdy SF. 2002. Regulation of G1 cell-cycle progression by oncogenes and tumor suppressor genes. Curr Opin Genet Dev 12(1): 47-52. Houghton JA, Houghton PJ, Wooten RS. 1979. Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine. Cancer Res 39(7 Pt 1): 2406-2413. Hung K, Hayashi R, Lafond-Walker A, Lowenstein C, Pardoll D, Levitsky H. 1998. The central role of CD4+ T cells in the antitumor immune response. J Exp Med 188(12): 2357-2368. Hutchison C, Glover DM. 1995. Cell cycle control. Oxford University Press. New York. Ikekawa T, Saitoh H, Feng W, Zhang H, Li L, Matsuzawa T. 1992. Antitumor activity of Hypsizigus marmoreus. I. Antitumor activity of extracts and polysaccharides. Chem Pharm Bull 40(7): 1954-1957. Inoue T, Anderson TD, Hayes TJ, Horii I. 1996. Comparative immunotoxicity assessment of N4-trimethoxybenzoyl-5'-deoxy-5-fluorocytidine (5'-DFUR) in BDF1 mice. J Toxicol Sci 21(1): 29-39. Isaacs A, Lindenmann J. 1957. Virus interference. 1. The interferon. Proc. R. Soc. Lond B Biol Sci 147(927): 258–267. Ito K, Nakazato T, Miyakawa Y, Yamato K, Ikeda Y, Kizaki M. 2003. Caffeine induces G2/M arrest and apoptosis via a novel p53-dependent pathway in NB4 promyelocytic leukemia cells. J Cell Physiol 196(2): 276-283. Jiang CM, Lai YJ, Chang WH, Wu MC, Chang HM. 2001. Pectinesterase inhibitor in jelly fig (Ficus awkeotsang Makino) achenes. J Food Sci 66(2): 225-228. Jiang CM, Li CP, Chang HM. 2002a. Influence of pectinesterase inhibitor from jelly fig (Ficus awkeotsang Makino) achenes on pectinesterases and cloud loss of fruit juices. J Food Sci 67(8): 3063-3068. Jiang CM, Li CP, Chang JC, Chang HM. 2002b. Characterization of pectinesterase inhibitor in jelly fig (Ficus awkeotsang Makino) achenes. J Agric Food Chem 50(17): 4890-4894. Jing Y, Nakajo S, Xia L, Nakaya K, Fang Q, Waxman S, Han R. 1999. Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines. Leuk Res 23(1): 43-50. Johnson DG, Walker CL. 1999. Cyclins and cell cycle checkpoints. Annu Rev Pharmacol Toxicol 39: 295-312. Johnson LV, Walsh ML, Chen LB. 1980. Localization of mitochondria in living cells with rhodamine 123. Proc Natl Acadf Sci 77(2): 990-994. Juan G, Cavazzoni M, Saez GT, O'Connor JE. 1994. A fast kinetic method for assessing mitochondrial membrane potential in isolated hepatocytes with rhodamine 123 and flow cytometry. Cytometry 15(4): 335-342. Julius, M. C. and Robert, E. L. 1999. Atlas of immunology. CRC press, Baca Raton. New York. Kaushansky K, Lin N, Adamson JW. 1988. Interleukin 1 stimulates fibroblasts to synthesize granulocyte- macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation. J Clin Invest 81(7): 92-97. Kikuchi A, Holan V, Minowada J. 1992. Effects of tumor necrosis factor alpha, interferon alpha and interferon gamma on non-lymphoid leukemia cell lines: growth inhibition, differentiation induction and drug sensitivity modulation. Cancer Immunol Immunother 35(4): 257-263. Kilpatrick DC 1999. Mechanisms and assessment of lectin-mediated mitogenesis. Mol Biotechnol 11(1): 55-65. Kimura Y, Okuda H. 1999. Prevention by chitosan of myelotoxicity, gastrointestinal toxicity and immunocompetent organic toxicity induced by 5-fluorouracil without loss of antitumor activity in mice. Jpn J Cancer Res 90(7): 765-774. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. 1997. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275(5303): 1132-1136. Kohn EA, Ruth ND, Brown MK, Livingstone M, Eastman A. 2002. Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation. J Biol Chem 277(29): 26553-26564. Komae K, Sone Y, Kakuta M, Misaki A. 1990. Purification and characterization of pectinesterase from Ficus awkeotsang. Agric Biol Chem 54(6): 1469-1476. Komoriya A, Packard BZ, Brown MJ, Wu ML, Henkart PA. 2000. Assessment of caspase activities in intact apoptotic thymocytes using cell-permeable fluorogenic caspase substrates. J Exp Med 191(11): 1819-1828. Konishi F, Mitsuyama M, Okuda M, Tanaka K, Hasegawa T, Nomoto K. 1996. Protective effect of an acidic glycoprotein obtained from culture of Chlorella vulgaris against myelosuppression by 5-fluorouracil. Cancer Immunol Immunother 42(5): 268-274. Korsmeyer SJ. 1992. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 80(4): 879-886. Kotenko SV, Gallagher G, Baurin VV, Lewis-Antes A, Shen M, Shah NK, Langer JA, Sheikh F, Dickensheets H, Donnelly RP. 2003. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 4(1): 69-77. Kouchi Y, Maeda Y, Morinaga H, Ohuchida A. 1996. Immunotoxic effects of a new antineoplastic agent S-1 in mice--comparison with S-1, UFT and 5-FU. J Toxicol Sci 21(Suppl-3): 691-701. Kuby J. 2000. Immunology. 4th ed. W. H. Freeman Co., New York. Kuo CL, Chou CC, Yung BYM. 1995. Berberine complexes with DNA in the berberine-induced apoptosis in human leukemic HL-60 cells. Cancer Lett 93(2): 193-200. Lahrer RI, Ganz T, Selsted ME, Babior BM, Curnutte JT. 1988. Neutrophils host defense. Am Int Med 109(2): 127-142. Lee M, MacMillan JD. 1968. Mode of action of pectin enzymes. I. Purification and certain properties of tomato pectinesterase. Biochem 7(11): 4005-4010. Lee YG, Kim JY, Lee KW, Kim KH, Lee HJ. 2003. Peptides from anchovy sauce induce apoptosis in a human lymphoma cell (U937) through the increase of caspase-3 and -8 activities. Ann N Y Acad Sci 1010: 399-404. Lee YS, Chung IS, Lee IR, Kim KH, Hong WS, Yun YS. 1997. Activation of multiple effector pathways of immune system by the antineoplastic immunostimulator acidic polysaccharide ginsan isolated from Panax ginseng. Anticancer Res 17: 323–331. Legdeur MC, Bontje PM, Ossenkoppele GJ, Beelen RH, van de Loosdrecht AA, Broekhoven MG, Langenhuijsen MM, Thijsen SF, Hofstee H, Schuurhuis GJ. 1996. The role of BCL-2 and bax protein in monocyte-mediated apoptosis in human leukemic cell lines. Exp Hematol 24(13): 1530-1539. Levine AJ. 1997. p53, the cellular gatekeeper for growth and division. Cell 88(3): 323-331. Li LY, Luo X, Wang X. 2001. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412(6842): 95-109. Li YC, Tyan YS, Kuo HM, Chang WC, Hsia TC, Chung JG. 2004 Baicalein induced in vitro apoptosis undergo caspases activity in human promyelocytic leukemia HL-60 cells. Food Chem Toxicol 42(1): 37-43. Liao HF, Chou CJ, Wu SH, Khoo KH, Chen CF, Wang SY. 2001. Isolation and characterization of an active compound from black soybean [Glycine max (L.) Merr.] and its effect on proliferation and differentiation of human leukemic U937 cells. Anticancer Drugs 12(10): 841-846. Lieu CW, Lee SS, Wang SY. 1992. The effect of Ganoderma lucidum on induction of differentiation in leukemic U937 cells. Anticancer Res 12(4): 1211-1216. Lin TP, Liu CC, Huang RS, Wang WY, Feng TY. 1990. Induction of pectin methylesterase in the pericarp of achenes of the jelly-fig Ficus awkeotsang Makino. Plant Cell Physiol 31(4): 533-537. Lin TP, Liu CC, Wang WY. 1989. Purification and characterization of pectin methylesterase from Ficus awkeotsang Makino achenes. Plant Physiol 91(4): 1445-1453. Liu F, Ooi VE, Liu WK, Chang ST. 1996. Immunomodulation and antitumor activity of polysaccharide-protein complex from the culture filtrates of a local edible mushroom, Tricholoma lobayense. Gen Pharmacol 27(4): 621-624. Liu X, Kim CN, Yang J, Jemmerson J, Wang X. 1996. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86(1) 147–157. Lotem J, Sachs L. 1987. Regulation of cell-surface receptors for hematopoietic differentiation-inducing protein MGI-2 on normal and leukemic myeloid cells. Int J Cancer 40(4): 532-539. Ludovico P, Sansonetty F, Côrte-Real M. 2001. Assessment of mitochondrial membrane potential in yeast cell populations by flow cytometry. Microbiology 147(12): 3335-3343. Lundberg AS, Weinberg RA. 1999. Control of the cell cycle and apoptosis. Euro J Cancer 35(4): 531-539. Mahida YR. 2000. The key role of macrophages in the immunopathogenesis of inflammatory bowel disease. Inflammatory Bowel Disease 6(1): 21-33. Maianski NA, Mul FP, van Buul JD, Roos D, Kuijpers TW. 2002. Granulocyte colony-stimulating factor inhibits the mitochondria-dependent activation of caspase-3 in neutrophils. Blood 99(2): 672-679. Maines MD, Costa LG., Reed DJ, Sassa S, Sipes IG. 1999. Current protocols in toxicology. John Wiley and Sons, New York. Makino M, Shoji H, Takemoto D, Honboh T, Nakamura S, Kurayoshi K, Kaibara N. 2001. Comparative study between daily and 5-days-a –week administration of oral 5-fluorouracil chemotherapy in mice: determining the superior regimen. Cancer Chemother Pharmacol 48(5): 370-374. Martin SJ, Reutelingsperger CPM, McGahon AJ, Rader JA, van Schie RCAA, LaFace DM, Green DR. 1995. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 182(5): 1545-1556 Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW, Creasy CL, Dingwall C, Downward J. 2002. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J Biol Chem 277(1): 439-444. McCabe MJ Jr, Singh KP, Reddy SA, Chelladurai B, Pounds JG, Reiners JJ Jr, States JC. 2000. Sensitivity of myelomonocytic leukemia cells to arsenite-induced cell cycle disruption, apoptosis, and enhanced differentiation is dependent on the inter-relationship between arsenic concentration, duration of treatment, and cell cycle phase. J Pharmacol Expl Ther 295(2): 724-733. McConnell BB, Gregory FJ, Stott FJ, Hara E, Peters G. 1999. Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol Cell Biol 19(3): 1981-1989. Meltzer MS, Occhionero M, Ruco LP. 1982. Macrophage activation for tumor cytotoxicity: regulatory mechanisms for induction and control of cytotoxic activity. Fed Proc 41(6): 2198-2205. Miller GM, Kim DW, Andres ML, Green LM, Gridley DS. 2003. Changes in the activation and reconstitution of lymphocytes resulting from total-body irradiation correlate with slowed tumor growth. Oncology 65(3): 229-241. Miyata H, Doki Y, Yamamoto H, Kishi K, Takemoto H, Fujiwara Y, Yasuda T, Yano M, Inoue M, Shiozaki H, Weinstein IB, Monden M. 2001. Overexpression of CDC25B overrides radiation-induced G2-M arrest and results in increased apoptosis in esophageal cancer cells. Cancer Res 61(7): 3188-3193. Morgan DO. 1997. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu Rev Cell Dev Bio 13: 261-91. Mukhtar H, Ahmad, N. 1999. Cancer chemoprevention: future holds in multiple agents. Toxicol Appl Pharmacol 158(3): 207-210. Munker R, Koeffler P. 1987. In vitro action of tumor necrosis factor on myeloid leukemia cells. Blood 69(4): 1102-1108. Murray AW. 2004. Recycling the cell cycle: cyclins revisited. Cell 116(2): 221-34. Ni J. Hollander D. 1996. Applications of the MTT assay to functional studies of mouse intestinal intraepithelial lymphocytes. J Clin Lab Anal 10(1): 42-52. Nomoto K, Yokokura T, Yoshikai Y, Mitsuyama M, Nomoto K. 1991. Induction of lethal infection with indigenous Escherichia coli in mice by fluorouracil. Can J Microbiol 37(3): 244-247. Nowell PC. 1960. Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. Cancer Res 20(4): 462-6. Nunez G, Benedict MA, Hu Y, Inohara N. 1998. Caspases: the proteases of the apoptotic pathway. Oncogene 17(25): 3237-3245. O'Connor JE, Vargas JL, Kimler BF, Hernandez-Yago J, Grisolia S. 1988. Use of rhodamine 123 to investigate alterations in mitochondrial activity in isolated mouse liver mitochondria. Biochem Biophys Rese Commun 151(1): 568-573. Olsson I, Olofsson T, Mauritzon N. 1981. Characterization of mononuclear blood cell-derived differentiation inducing factors for the human promyelocytic leukemia cell line HL-60. J Natl Cancer Inst 67(6): 1225-1230. Olsson IL, Sargadharan MG, Breitman TR, Gallo RC. 1984. Isolation characterization of a T lymphocyte-derived differentiation inducing factor for the myeloid leukemic cell line HL-60. Blood 63(3): 510-517. Onozaki K, Urawa H, Tamatani T, Iwamura Y, Hashimoto T, Baba T, Suzuki H, Yamada M, Yamamoto S, Oppenheim JJ. 1988. Synergistic interactions of interleukin 1, interferon-β, and tumor necrosis factor in terminally differentiating a mouse myeloid leukemic cell line (M1). Evidence that interferon-βis an autocrine differentiating factor. J Immunol 140(1): 112-119. Panasiuk R, Amarowicz R, Kostyra H, Sijtsma L. 1998. Determination of α-amino nitrogen in pea protein hydrolysates: a comparison of three analytical methods. Food Chem 62(3): 363-367. Pandey P, Saleh A, Nakazawa A, Kumar S, Srinivasula SM, Kumar V, Weichselbaum R, Nalin C, Alnemri ES, Kufe D, Kharbanda S. 2000. Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO 19(16): 4310-4322. Park JW, Choi YJ, Jang MA, Lee YS, Jun DY, Suh SI, Baek WK, Suh MH, Jin IN, Kwon TK. 2001. Chemopreventive agent resveratrol, a natural product derived from grapes, reversibly inhibits progression through S and G2 phases of the cell cycle in U937 cells. Cancer Letters 163(1): 43-49. Parone PA, James D, Martinou JC. 2002. Mitochondria: regulating the inevitable. Biochimie 84(2-3): 105-111. Perez-Cruz I, Carcamo JM, Golde DW. 2003. Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells. Blood 102(1): 336-343. Pestka S, Langer JA, Zoon KC, Samuel CE. 1987. Interferons and their actions. Annu Rev Biochem 56: 727-777. Petit PX, O'Connor JE, Grunwald D, Brown SC. 1990. Analysis of the membrane potential of rat- and mouse-liver mitochondria by flow cytometry and possible applications. Eur J Biochem 194(2): 389-397. Piao W, Yoo J, Lee DK, Hwang HJ, Kim JH. 2001. Induction of G2/M phase arrest and apoptosis by a new synthetic anti-cancer agent, DW2282, in promyelocytic leukemia (HL-60) cells. Biochem Pharmacol 62(11): 1439-1447. Powrie F, Coffman RL. 1993. Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunology Today 14(6): 270-274. Pradhan D, Krahling S, Williamson P, Schlegel RA. 1997. Multiple systems for recognition of apoptotic lymphocytes by macrophages. Mol Biol Cell 8(5): 767-778. Rabbins SL. 1967. Pathology, 3rd ed. Saunders, Philadelphia. Ralph P, Harris PE, Punjabi CJ, Welte K, Litcofsky PB, Ho MK, Rubin BY. Moore MA, Springer TA. 1983. Lymphokine inducing “terminal differentiation” of the human monoblast leukemia line U937: a role for g interferon. Blood 62(6): 1169-1175. Reuther JY, Baldwin AS Jr. 1999. Apoptosis promotes a caspase-induced amino-terminal truncation of IkappaBalpha that functions as a stable inhibitor of NF-kappaB. J Biol Chem 274(29): 20664-20670. Rice SC, Vacek P, Homans AH, Messier T, Rivers J, Kendall H, Finette BA. 2004. Genotoxicity of therapeutic intervention in children with acute lymphocytic leukemia. Cancer Res 64(13): 4464-4471 Robinson E, Segal R, Struminger L, Faraggi D, El'ad-Yarum R, Mekori T. 1999. Lymphocyte subpopulations in patients with multiple primary tumors. Cancer 85(9): 2073-2076. Rosse T, Olivier R, Monney L, Rager M, Conus S, Fellay I, Jansen B, Borner C. 1998. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature 391(6666): 496-499. Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP. 1995. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 382(6589): 325-331. Ryan KM, Phillips AC, Vousden KH. 2001. Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol 13(3): 332-337. Ryan L, O'Callaghan YC, O'Brien NM. 2004. Generation of an oxidative stress precedes caspase activation during 7beta-hydroxycholesterol-induced apoptosis in U937 cells. J Biochem Mol Toxicol 18(1): 50-59. Sakagami H, Ikeda M, Konno K. 1989. Stimulation of tumor necrosis factor-induced human myelogenous leukemic cell differentiation by high molecular weight PSK subfraction. Biochem Biophys Res Commu 162(2): 597-603. Sakagami H, Sugaya K, Utsumi A, Fujinaga S, Sato T, Takeda M. 1993. Stimulation by PSK of interleukin-1 production by human peripheral blood mononuclear cells. Anticancer Res 13(3): 671-676. Sakai I, Tanaka T, Osawa S, Hashimoto S and Nakaya K. 1993. Geranylgeranylacetone used as an antiulcer agent is a potent inducer of differentiation of various human myeloid leukemia cell lines. Biochem Biophys Res Commun 191(3): 873-879. Salgame P, Abrams JS, Clayberger C, Goldstein H, Convit J, Modlin RL, Bloom BR. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254(5029): 279-282. Saltz L. 1991. Drug treatment of colorectal cancer. Current status. Drugs 42(4): 616-627. Salvesen GS, Dixit VM. 1997. Caspases: intracellular signaling by proteolysis. Cell 91(4): 443-446. Samali A, Cai J, Zhivotovsky B, Jones DP, Orrenius S. 1999. Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells. EMBO J 18(8): 2040-2048. Schlegel RA, Williamson P. 2001. Phosphatidylserine, a death knell. Cell Death Differ 8(6): 551-563. Schmoll HJ, Buchele T, Grothey A, Dempke W. 1999. Where do we stand with 5-fluorouracil? Semin Oncol 26(6): 589-605. Schuetz JD, Wallace HJ, Diasio RB. 1984. 5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity. Cancer Res 44(4): 1358-1363. Schuurhuis DH, Laban S, Toes RE, Ricciardi-Castagnoli P, Kleijmeer MJ, van der Voort EI, Rea D, Offringa R, Geuze HJ, Melief CJ, Ossendorp F. 2000. Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli. J Exp Med 192(1): 145-150. Shah A, MacDonald W, Goldie J, Gudauskas G, Brisebois B. 1985. 5-FU infusion in advanced colorectal cancer: comparison of three dose schedules. Cancer Treat Rep 69(7-8): 739-742. Sheng H, Shao J, Morrow JD, Beauchamp RD, DuBois RN. 1998. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res 58(2): 362-366. Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM. 2003. IL-28, IL-29 and their class II cytokine receptor IL-28R Nat Immunol 4(1): 63-68. Sherr CJ, Roberts JM. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13(12): 1501-1512. Sherr CJ. 1996. Cancer cell cycles. Science 274(5293): 1672-1977. Sherr CJ. 2000. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res 60(14): 3689-3695. Sheu BC, Hsu SM, Ho HN, Lin RH, Torng PL, Huang SC. 1999. Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes are correlated with the progression of human cervical carcinoma. Cancer 86(8): 1537-1543. Shi Y. 2002. Mechanisms of Caspase Activation and Inhibition during Apoptosis. Mol Cell 9(3): 459-470. Snyder SH. 1992. Nitric oxide: first in a new class of neurotransmitters. Science 257(5069): 494-496. Steel R, Doherty JP, Buzzard K, Clemons N, Hawkins CJ, Anderson RL. 2004. Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1. Biol Chem 279(49): 51490-51499. Stevaux O, Dyson NJ. 2002. A revised picture of the E2F transcriptional network and RB function. Curr Opin Cell Biol 14(6): 684-91. Sundström C, Nilsson K. 1976. Establishment characterization of a human histiocytic lymphoma cell line (U-937). Int J Cancer 17(5): 565-577. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G. 1999. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397(6718): 441-446. Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R. 2001. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 8(3): 613-621. Takaku T, Kimura Y, Okuda H. 2001. Isolation of an antitumor compound from Agricus Blazei Murill and its mechanism of action. J Nutr 131(5): 1409-1413. Takeda K, Iwamoto S, Sugimoto H, Takuma T, Kawatani N, Noda M, Masaki A, Morise H, Arimura H, Konno K. 1986. Identity of differentiation inducing factor and tumour necrosis factor. Nature 323(6086): 338-340. Takeda K, Minowada J, Bloch A. 1993. Differential ability of mitogen-stimulated human leukocyte-conditioned media to induce Fc receptors in human leukemia cells. Cell Immunol 79(2): 288-297. Tamatani T, Kimura S, Hashimoto T, Onozaki K. 1989. Purification of guinea pig tumor necrosis factor (TNF): comparison of its antiproliferative and differentiative activities for myeloid leukemic cell lines with those of recombinant human TNF. J Biochem 105(1): 55-60. Tang X, Halleck MS, Schlegel RA, Williamson P. 1996. A subfamily of P-type ATPases with aminophospholipid transporting activity. Science 272(5267): 1495-1497. Thomas J, Liu F, Link DC. 2002. Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor. Curr Opin Hematol 9(3): 183-189. Thornberry NA, Lazebnik Y. 1998. Caspases: enemies within. Science 281 (5381):1312-1316. Tseng SH, Hwang LH, Lin SM. 1997. Induction of antitumor immunity by intracerebrally implanted rat C6 glioma cells genetically engineered to secrete cytokines. J Immunother 20(5): 334-342. Tsujimoto Y. 2003. Cell death regulation by the Bcl-2 protein family in the mitochondria. J Cell Physiol 195(2): 158-167. Ueda N, Shah SV. 1994. Apoptosis. J Lab Clin Med 124(2): 169-77. van Loo G, van Gurp M, Depuydt B, Srinivasula SM, Rodriguez I, Alnemri ES, Gevaert K, Vandekerckhove J, Declercq W, Vandenabeele P. 2002. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ 9(1): 20-26. Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB. 1997. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 91(5): 627-637. Vassalli P. 1992. The pathophysiology of tumor necrosis factors. Annu Rev Immunol 10: 411-452. Veis DJ, Sentman CL, Bach EA, Korsmeyer SJ. 1993. Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J Immunol 151(5): 2546-2554. Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL. 2000. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102(1): 43-53. Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ, Vaux DL. 2002. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J Biol Chem 277(1): 445-454. Verhoven B, Krahling S, Schlegel RA, Williamson P. 1999. Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes. Cell Death Differ 6(3): 262-270. Verhoven B. Schlegel RA, Williamson P. 1995. Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes. J Exp Med 182(5): 1597-1601. Vilcek J, Feldmann M. 2004. Historical review: Cytokines as therapeutics and targets of therapeutics. Trends Pharmacol Sci 25(4): 201-209. Vilcek J, Lee TH. 1991. Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions. J Biol Chem 266(12): 7313-7316. Wang HX, Liu WK, Ng TB, Ooi VE, Chang ST. 1996a. The immunomodulatory and antitumor activities of lectins from the mushroom Tricholoma mongolicum. Immunopharmacology 31(2-3): 205-211. Wang HX, NG TB, Liu WK, Ooi VE, Chang ST. 1996b. Polysaccharide-peptide complexes from the cultured mycelia of the mushroom Coriolus versicolor and their culture medium activate mouse lymphocytes and macrophages. Int J Biochem Cell Biol 28(5): 601-607. Wang HX, Ng TB, Ooi VE, Liu WK, Chang ST. 1996c. A polysaccharide-peptide complex from cultured mycelia of the mushroom Tricholoma mongolicum with immunoenhancing and antitumor activities. Biochem Cell Biol 74(1): 95-100. Wang JC, Hu SH, Su CH, Lee TM. 2001. Antitumor and immunoenhancing activities of polysaccharide from culture broth of Hericium spp. Kaohsiung J Med Sci 17(9): 461-467. Wang M, Bronte V, Chen PW, Gritz L, Panicali D, Rosenberg SA, Restifo NP. 1995a. Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen. J Immunol 154(9): 4685-4692. Wang M, Chen PW, Bronte V, Rosenberg SA, Restifo NP. 1995b. Anti-tumor activity of cytotoxic t lymphocytes elicited with recombinant and synthetic forms of a model tumor-associated antigen. J Immunother Emphasis Tumor Immunol 18(3): 139-146. Wang SY, Chen LY, Wang SJ, Lin CK, Ho CK. 1991. Growth inhibition and differentiation in HL-60 leukemia cells induced by 1,25-dihydroxyvitamin D3 and tumor necrosis factor alpha. Exp Hematol 19(10): 1025-1030. Wang SY, Hsu ML, Hsu HC, Tzeng CH, Lee SS, Shiao MS, Ho CK. 1997. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Immunopharmac 70(6): 699-705. Williamson P, Schlegel RA. 1994. Back and forth: the regulation and function of transbilayer phospholipid movement in eukaryotic cells. Mol Memb Biol 11(4): 199-216. Xanthoudakis S, Roy S, Rasper D, Hennessey T, Aubin Y, Cassady R, Tawa P, Ruel R, Rosen A, Nicholson DW. 1999. Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis. EMBO J 18(8): 2049-2056. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. 1993. p21 is a universal inhibitor of cyclin kinases. Nature 366(6456): 701-704. Yam LT, Li CY, Crosby WH. 1971. Cytochemical identification of monocytes and granulocytes. Am J Cli Pathol 55(3): 283-290. Yamamoto S, Kurebayashi J, Kurosumi M, Kunisue J, Otsuki T, Tanaka K, Sonoo H. 2001. Combined effects of docetaxel and fluoropyrimidines on tumor growth and expression of interleukin-6 and thymidine phosphorylase in breast cancer xenografts. Cancer Chem Phar 48(4): 283-288. Yamamoto Y, Tomida M, Hozumi M. 1980. Production of mouse spleen cells of factors stimulating differentiation of mouse leukemic cells that differ from colony-stimulating factor. Cancer Res 40(12): 4804-4809. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X. 1997. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275(5303): 1129-1132. Zhang ZG, Harstrick A, Rustum YM. 1992. Mechanisms of resistance to fluoropyrimidines. Semin Oncol 19(2 Suppl 3): 4-9. Zhivotovsky B, Orrenius S, Brustugun OT, Doskeland SO. 1998. Injected cytochrome c induces apoptosis. Nature 391(6666): 449-450. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. 1997. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90(3): 405-413. | zh_TW |
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