Protective Effects of Foxtail Millet and Dehulled Adlay on a Nonsteroidal Anti-inflammatory Drug-induced Gastric Mucosal Injury in Rats
Date Issued
2008
Date
2008
Author(s)
Chan, Lu-Chi
Abstract
The use of non-steroidal anti-inflammatory drugs (NSAIDs) can be associated with severe adverse effects of the digestive system (e.g. gastric ulcer). The principle ulcerogenic action of NSAIDs appears to work through their systemic inhibition of the cyclooxygenase (COX) enzyme, which catalyzes the formation of prostaglandins (PG). As a consequence of PG reduction, mucosal defense and repair mechanisms, such as gastric NPSH or mucus, are suppressed. Due to suppressed mucosal protective system, the corresponding attack of gastric acid, pepsin and drugs are enhanced, which lead to gastric ulceration. The present study was to investigate the abilities of foxtail millet and dehulled adlay to prevent lesions in the stomach individually and in combination on indomethacin (a NSAID) -induced gastric mucosal injury in rats. The results of this study demonstrated that rats fed with three different diets containing 1)foxtail millet (10%), 2)dehulled adlay (30%) and 3)mixture of millet and adlay (40%, foxtail millet plus dehulled adlay, the ratio is 1:3) had lowered gastric ulcer index (protective potency were 61%, 68%, 80% respectively) , reduced levels of lipid peroxidation in blood, stomach and liver, and enhanced degree of gastric prostaglandin E2 synthesis in stomach by 4 times (protective potency ranged from 14~16%). A positive trend of NPSH production was also observed. All of the results were comparable to the effects of positive control misoprostol, however, there was no significant difference between these treatment groups. Our finding showed that foxtail millet and/or dehulled adlay prevented macroscopic or microscopic indomethacin-induced gastric damage by decreasing oxidative damage and reverting the depletion of PGE2 induced by indomethacin significantly. This study suggested the feasibility of using foxtail millet and/or dehulled adlay for protecting humans from digestive disorder (e.g. gastric ulcer).ey words: foxtail millet, dehulled adlay, non-steroidal anti-inflammatory drugs (NSAIDs), acute gastric mucosal lesions
Subjects
foxtail millet
dehulled adlay
non-steroidal anti-inflammatory drugs (NSAIDs)
acute gastric mucosal lesions
Type
thesis
File(s)![Thumbnail Image]()
Loading...
Name
ntu-97-R95641033-1.pdf
Size
23.53 KB
Format
Adobe PDF
Checksum
(MD5):48a4cbffe3f2feb72f95b8f9b57562bf