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  4. Investigation on the percutaneous absorption of media-milled yam
 
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Investigation on the percutaneous absorption of media-milled yam

Date Issued
2015
Date
2015
Author(s)
Lu, Sha-Li
URI
http://ntur.lib.ntu.edu.tw//handle/246246/273915
Abstract
Skin aging is associated with skin thinning, atrophy, dryness, wrinkling. Nowadays, there are several methods to relieve this issue, such as plastic surgery, laser rejuvenation, and skincare products with natural compound. Yam (Dioscorea spp.) has been consumed as a food and medicine around the world. Diosgenin, an aglycon of the yam steroid saponin, has been found to exhibit health benefits, including reduction of pigmentation and enhancing WS1 cells to secrete more collagen. The phytosterols in yam are stigmasterol and β-sitosterol, which enhance water holding capacity and yield wound healing effect. Nanocosmetics is a novel application of nanotechnology. Nano/submicron yam can be potential material for nanocosmetics. In this study, Keelung yam (Dioscorea pseudojaponica Yamamoto) was purchased from Rueifang Farmer’s Association, and the aim of study was to investigate the physical properties of media-milled yam and its percutaneous absorption effect. Raw yam powder was used as a control and a blended yam were utilized for comparasion with media-milled yam. The number mean diameter of raw yam powder was 4.95 ± 0.01 μm, blended yam was 4.93 ± 0.01 μm, after two-steps media-milling, number mean diameter was decreased to 0.10 ± 0.00 μm. The pH value of blended yam and media-milled yam are both between 5 ~ 8, and in this range, with zeta-potential of -20 ~ -40 mV, indicating a stable media-milled suspension. In sedimentation test, media-milled yam was more stable than the blended group. The media-milled yam was precipitated slowly after 5 hours. Active compounds such as diosgenin, β-sitosterol and stigmasterol are increased after media-milling. Application of blended yam and media-milled yam to the skin for 12 hours did not result in any damage to skin. However, active compounds in yam were not detected in epidermis, dermis and receiver, probably due to the limitation of HPLC analytical sensitivity, particle size and the molecular weight of compounds.
Subjects
media-milling
percutaneous absorption
yam
skin-aging
Type
thesis
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ntu-104-R01641026-1.pdf

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