https://scholars.lib.ntu.edu.tw/handle/123456789/98107
標題: | Effect of bovine colostrum on the growth inhibition and differentiation of human leukemic U937 cells | 作者: | Ma, Chia-Yu Kung, Hua-Ting Chen, Jian-Nan Chang, Chi-Yue Chang, Huang-Min Wu, James Swi-Bea |
關鍵字: | Antitumour; Colostrum; Cytokine; Differentiation; Leukemic cell; Mononuclear cell | 公開日期: | 2009 | 起(迄)頁: | 965-969 | 來源出版物: | Journal of the Science of Food and Agriculture | 摘要: | BACKGROUND: Colostrum is the breast milk of female mammals produced within in a short time after giving birth. It is thought to protect neonates from infection as well as to facilitate immune system maturation. In this study the effect of bovine colostrum on the proliferation and differentiation of human leukemic U937 cells was investigated to understand more about its immunomodulatory activity. RESULTS: Human mononuclear cells (MNCs) were stimulated with bovine colostrum (CS) and then filtered to obtain a conditioned medium (CM) (CS-MNC-CM). CS-MNC-CMs prepared with day 1 to day 4 colostrums inhibited U937 cells by 39.4-64.4%. The expressions of surface markers CD11b and CD14 on U937 cells in the treated groups were 30.6-33.5% and 40.0-42.6% respectively. High levels of cytokines IL-1β, IFN-γ and TNF-α were detected in CS-MNC-CMs. CONCLUSION: Evidence indicates that colostrums stimulate human MNCs to secrete cytokines IL-1β, IFN-γ and TNF-α which subsequently inhibit the growth of U937 cells and induce their differentiation into mature monocytes and macrophages. There is a possibility for bovine colostrum to be processed into an anti-leukemia ingredient for use in health foods. ? 2009 Society of Chemical Industry. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/189840 | DOI: | 10.1002/jsfa.3539 | SDG/關鍵字: | Bovinae; Mammalia |
顯示於: | 食品科技研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。