Juan, Yun-TingYun-TingJuanWEN-CHIH CHIANGWEI-CHOU LINYang, Cheng-WenCheng-WenYangChou, San-FangSan-FangChouHung, Ruo-WeiRuo-WeiHungChiu, Yen-LingYen-LingChiu2022-09-152022-09-152022-07-212077-0383https://scholars.lib.ntu.edu.tw/handle/123456789/620496Our prior study indicates a close relationship between alternative complement pathway activation, galactose-deficient IgA1 (Gd-IgA1) concentration and clinical severity of IgA nephropathy (IgAN). Nonetheless, the relationship between complement factors and the updated Oxford classification of IgAN remains unclear. This study enrolled eighty-four previously untreated, biopsy-diagnosed IgAN patients. The clinical and laboratory findings were collected at the time of biopsy. Plasma levels of complement factor C5a, factor Ba and Gd-IgA1 were measured and analyzed. It was found that the levels of proteinuria positively correlated with the updated Oxford classification of mesangial hypercellularity (M), endocapillary hypercellularity (E), tubular atrophy/interstitial fibrosis (T) and crescents (C). In addition, plasma Gd-IgA1 titer was significantly elevated in IgAN patients with tubular atrophy/interstitial fibrosis (T). In separate multivariable logistic regression models, both Gd-IgA1 and factor Ba independently predict higher T scores. The results indicate that both the levels of Gd-IgA1 antibody and biomarkers of the alternative complement pathway activation reflect the Oxford classification of IgAN. Whether these biomarkers can be used to guide therapeutic decisions requires further study.enIgA nephropathy; Oxford classification; complement C5a; factor Ba; galactose-deficient IgA1[SDGs]SDG3journal article10.3390/jcm11144231358879952-s2.0-85137218656WOS:000832331000001https://api.elsevier.com/content/abstract/scopus_id/85137218656