2012-08-012024-05-14https://scholars.lib.ntu.edu.tw/handle/123456789/656102摘要：計畫名稱：治療後尿路動力學所見正常化作為女性膀胱過動病例接受抗毒蕈鹼藥物治癒的客觀指標，以及探討排尿日誌與問卷變化與此指標的關聯性。背景/目標:膀胱過動症(OAB)大約影響17%的婦女。但是OAB之致病機轉至今仍複雜不清。目前文獻上治療前後尿路動力學之改變型態是否可作為客觀的藥物治療成效罕有研究。因此本研究目標為治療後尿路動力學所見變為正常作為女性膀胱過動病例接受抗毒蕈鹼藥物治癒的客觀指標，以及探討排尿日誌與問卷變化與此指標的關聯性。病人及方法:預計於三年內於台大醫院婦產科收集300 個OAB 案例分析服用十二週Solifenacin 藥物前後之下列變化包括:自覺膀胱狀況問卷(perception of bladdercondition)、中文版OABSS 問卷中文版UDI-6 & IIQ-7 問卷、中文版King’s Health問卷,排尿日記、二十分鐘護墊試驗和尿路動力學檢查。預期成果:300 個女性OAB病患約有23%治療後尿路動力學所見變為正常，進一步分析可以得到排尿日誌及問卷變化與此指標的關聯性。 我們可以藉此找出治療後尿路動力學之正常化是否可作為一客觀的藥物治癒指標；以及治療停藥後在追蹤期間有多少個案會復發，並進一步分析其危險因子。<br> Abstract: 計畫名稱：Post-treatment Normallized Urodynamic Findings as the Golden Standard ofObjective Cure for Female Overactive Bladder Patients Receiving AntimuscarinicDrug and its Correlations with Voiding Diary, King’s Health Questionnaire, andOveractive Bladder Symptom Scores and Patient Perception of Bladder ConditionBackground/Purpose: Overactive bladder syndrome (OAB) affects around 17 % offemale population. However, the etiology of OAB is complicated and unclear inmany aspects. In particular, the research about the urodynamic patterns aftertreatment as an objective parameter of therapeutic efficify was paucity.Therefore the aims of our study were (1) to analyze the percentage of normalizedurodynamic pattern after treatment; (2) to analyze the associations of thenormalized urodynamic findings and changes of voiding diary, questionnaires andperception of bladder condition.Patients and Methods: We will perform a prospective study to recruit 300 femaleOAB patients at the outpatient clinic of Department of Obstetrics and Gynecologyof National Taiwan University Hospital. All OAB female patients will be askedto complete perception of bladder condition, Overactive bladder symptom scores,UDI-6&IIQ-7 and King’s Health questionnaires, voiding diary, 20-min pad testand urodynamic studies before and after 12 weeks’Solifenacin treatment. STATAsoftware was used for statistical analyses.Expected Results: Of the 300 female OAB patients, 23 % of cases will havenormalized urodynamic findings. With the comparisons of the normalizedurodynamic patterns after antimuscarinic treatment, we can answer the questionsthat (1) the percentage of normalized urodynamic pattern after treatment; (2)the associations of the normalized urodynamic findings and changes of voidingdiary, questionnaires and perception of bladder condition, then we can answerwhether normalized urodynamic findings can be used as a golden standard ofobjective cure; (3) the percentage of recurrence rates after treatment duringfollow-up and further to analyze the risk factors of recurrence.治療後尿路動力學所見正常化作為女性膀胱過動病例接受抗毒蕈鹼藥物治癒的客觀指 標，以及探討排尿日誌與問卷變化與此指標的關聯性。 背景/目標:膀胱過動症(OAB)大約影響17%的婦女。但是OAB之致病機轉至今仍複雜不 清。目前文獻上治療前後尿路動力學之改變型態是否可作為客觀的藥物治療成效罕有研 究。因此本研究目標為治療後尿路動力學所見變為正常作為女性膀胱過動病例接受抗毒 蕈鹼藥物治癒的客觀指標，以及探討排尿日誌與問卷變化與此指標的關聯性。 病人及方法:預計於三年內於台大醫院婦產科收集300 個OAB 案例分析服用十二週 Solifenacin 藥物前後之下列變化包括:自覺膀胱狀況問卷(perception of bladder condition)、中文版OABSS 問卷中文版UDI-6 & IIQ-7 問卷、中文版King’s Health 問卷,排尿日記、二十分鐘護墊試驗和尿路動力學檢查。 預期成果:300 個女性OAB病患約有23%治療後尿路動力學所見變為正常，進一步分析可 以得到排尿日誌及問卷變化與此指標的關聯性。 我們可以藉此找出治療後尿路動力學 之正常化是否可作為一客觀的藥物治癒指標；以及治療停藥後在追蹤期間有多少個案 會復發，並進一步分析其危險因子。Post-treatment Normallized Urodynamic Findings as the Golden Standard of Objective Cure for Female Overactive Bladder Patients Receiving Antimuscarinic Drug and its Correlations with Voiding Diary, King’s Health Questionnaire, and Overactive Bladder Symptom Scores and Patient Perception of Bladder Condition Background/Purpose: Overactive bladder syndrome (OAB) affects around 17 % of female population. However, the etiology of OAB is complicated and unclear in many aspects. In particular, the research about the urodynamic patterns after treatment as an objective parameter of therapeutic efficify was paucity. Therefore the aims of our study were (1) to analyze the percentage of normalized urodynamic pattern after treatment; (2) to analyze the associations of the normalized urodynamic findings and changes of voiding diary, questionnaires and perception of bladder condition. Patients and Methods: We will perform a prospective study to recruit 300 female OAB patients at the outpatient clinic of Department of Obstetrics and Gynecology of National Taiwan University Hospital. All OAB female patients will be asked to complete perception of bladder condition, Overactive bladder symptom scores, UDI-6&IIQ-7 and King’s Health questionnaires, voiding diary, 20-min pad test and urodynamic studies before and after 12 weeks’Solifenacin treatment. STATA software was used for statistical analyses. Expected Results: Of the 300 female OAB patients, 23 % of cases will have normalized urodynamic findings. With the comparisons of the normalized urodynamic patterns after antimuscarinic treatment, we can answer the questions that (1) the percentage of normalized urodynamic pattern after treatment; (2) the associations of the normalized urodynamic findings and changes of voiding diary, questionnaires and perception of bladder condition, then we can answer whether normalized urodynamic findings can be used as a golden standard of objective cure; (3) the percentage of recurrence rates after treatment during follow-up and further to analyze the risk factors of recurrence.膀胱過動症逼尿肌過動抗毒蕈鹼藥物尿路動力學檢查膀胱過度敏感overactive bladder syndromederusor overactivityantimuscarinic drugurodynamic studiesbladder oversensitivity